用DART-ToF-MS谱法检测阿尔及利亚糖菌提取物中潜在的二硫代吡洛酮类抗生素的结构

IF 0.6 Q4 CHEMISTRY, MULTIDISCIPLINARY

Kemija u Industriji-Journal of Chemists and Chemical Engineers Pub Date : 2022-07-20 DOI:10.15255/kui.2021.083

N. Bouras, Basel F. Alrayes, Salim Mokrane, Hadj Daoud Bouras, M. Holtz, A. Badjah-Hadj-Ahmed

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引用次数: 0

摘要

二硫代吡咯酮类抗生素由撒哈拉菌丝体细菌阿尔及利亚Saccharothrix algeriensis生产，以其强大的生物活性而闻名。采用实时和飞行时间质谱(DART-ToF-MS)直接分析方法对阿尔及利亚葡萄培养液进行生化分析。用这种技术对二硫代吡洛酮类药物进行的其他研究尚未发表。通过精确的质量测量和相应的分子式，对11个二硫代吡咯酮衍生物进行了表征:硫柳酮、丁基吡咯氨酸/异丁基吡咯氨酸、六烷基吡咯氨酸/异丙基吡咯氨酸、戊基吡咯氨酸/异戊基吡咯氨酸、2-甲基-3-戊基吡咯氨酸/2-己基吡咯氨酸、异己基吡咯氨酸和苯甲酰吡咯氨酸。所得结果证实，DART-ToF-MS是一种有效、快速筛选和表征细菌次级代谢物的合适验证技术。

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Structure of Potential Dithiolopyrrolone Antibiotics Detected from the DART-ToF-MS Spectra of Saccharothrix algeriensis Extract

Dithiolopyrrolone antibiotics, produced by the Saharan mycelial bacterium Saccharothrix algeriensis , are known for their potent biological activities. Biochemical profiling of S. algeriensis culture extract was done by direct analysis in real time and time-of-flight mass spectrometry (DART-ToF-MS). No other study on dithiolopyrrolones by this technique has been published. Eleven dithiolopyrrolone derivatives: thiolutin, butyryl-pyrrothine/iso-butyryl-pyrrothine, senecioyl-pyrrothine/tigloyl-pyrroth-ine, valeryl-pyrrothine/iso-valeryl-pyrrothine, 2-methyl-3-pentenyl-pyrrothine/2-hexonyl-pyrrothine, iso-hexanoyl-pyrrothine and benzoyl-pyrrothine were characterised by their exact mass measurement and the corresponding molecular formula of each compound. The obtained results confirmed that DART-ToF-MS is an appropriate confirmatory technique for powerful and rapid screening, as well as characterisation of bacterial secondary metabolites.

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来源期刊

Kemija u Industriji-Journal of Chemists and Chemical Engineers CHEMISTRY, MULTIDISCIPLINARY-

自引率

28.60%

发文量

审稿时长

24 weeks

期刊介绍： Kemija u industriji (Chemistry in industry) is monthly journal which is being published already for almost 60 years continually and from very beginning it is a journal of chemists and chemical engineers. It is official journal of Croatian Society of Chemists and Engineers and of Croatian Chemical Society. It is edited by Croatian Society of Chemists and Engineers.