丁胆碱酯酶在阿尔茨海默病发病机制中的作用

Q4 Medicine

中国现代神经疾病杂志 Pub Date : 2017-12-25 DOI:10.3969/CJCNN.V17I12.1711

Hao-bin Wu, Xu-dong Li, D. Peng, J. Jiao, Yan-feng Li, P. Yu, Yong Ji

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引用次数: 1

摘要

阿尔茨海默病(AD)是一种病因和发病机制尚不清楚的神经退行性疾病。AD的典型病理改变包括β-淀粉样蛋白(Aβ)沉积的神经性斑块[NPs，老年斑(SPs)]和由于tau蛋白异常聚集导致的神经原纤维缠结(nft)。研究表明，胆碱能系统与AD有关，而丁酰胆碱酯酶(BChE)在AD中起重要作用。本文就BChE在AD发病机制中的重要作用进行综述。DOI: 10.3969 / j.issn.1672-6731.2017.12.013

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The role of butyrylcholinesterase in the pathogenesis of Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disease of unknown etiology and pathogenesis. The typical pathological changes of AD include neuritic plaques [NPs, senile plaques (SPs)] with deposition of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) due to abnormal aggregation of tau protein. Researches show that cholinergic system is related to AD, and butyrylcholinesterase (BChE) plays an important role in AD. This article reviews the important role of BChE in the pathogenesis of AD. DOI: 10.3969/j.issn.1672-6731.2017.12.013

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