重铬酸钾和左炔诺孕酮联合暴露对雌性大鼠肾脏的毒理学影响

K. Akinwumi, S. T. Oloyede, O. O. Eleyowo, A. Jubril
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引用次数: 1

摘要

在我们的环境中,共同接触铬酸盐(VI)化合物和口服避孕药是很常见的,尤其是在铬酸盐相关行业工作的女性中。接触铬酸盐(VI)或口服避孕药与包括癌症和肾损伤在内的几种疾病的病因有关。然而,关于同时暴露于这两种化合物的毒性影响的信息很少。本研究考察了重铬酸钾(PDC)和口服避孕药左炔诺孕酮联合暴露对雌性大鼠肾脏的毒性。对照动物喂食蒸馏水,而实验大鼠每周注射一次12 mg/kg体重的PDC,持续六周,每天口服15µg/kg体重的左炔诺孕酮,单独或联合使用。在对照和实验大鼠的血浆和肾脏中评估绝对和相对肾脏重量、肾功能、氧化应激和病理损伤。PDC和左炔诺孕酮显著(p<0.05)增加了治疗大鼠的血浆尿素肌酐和丙二醛水平,而两种化合物降低了肾脏超氧化物歧化酶和谷胱甘肽-S-转移酶的活性。此外,在PDC治疗的大鼠肾脏中观察到包括坏死性肾炎在内的组织病理学损伤,而在左炔诺孕酮治疗的大白鼠中观察到肾小管上皮变性和坏死。同时暴露于这两种化合物会加重尿素、肌酸酐和肾损伤的增加。此外,抗氧化酶在联合治疗组中被进一步抑制。研究表明,重铬酸钾和左炔诺孕酮联合暴露会增加氧化应激,从而加重大鼠的肾毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toxicological Outcome of Combined Exposure to Potassium Dichromate and Levonorgestrel in the Kidney of Female Rats
Co-exposure to chromate (VI) compound and oral contraceptives is common in our environment especially among women working in chromate-related industries. Exposure to either chromate (VI) or oral contraceptives is linked with the etiology of several diseases including cancers and renal injury. However, there is paucity of information on the toxic effect of combined co-exposure to both compounds. The present study examines the toxicity of combined exposure to potassium dichromate (PDC) and an oral contraceptive, levonorgestrel in the kidney of female rats. Control animals were fed distilled water, while experimental rats were injected 12 mg/kg body weight of PDC once a week for six weeks and oral daily exposure to 15µg/kg body weight of levonorgestrel either alone or in combination. Absolute and relative kidney weight, renal function, oxidative stress and pathological lesion were assessed in plasma and kidney of control and experimental rats. The PDC and levonorgestrel significantly (p<0.05) increased plasma urea creatinine and malondialdehyde levels in treated-rats, while renal superoxide dismutase and glutathione-S-transferase activities were reduced by both compounds. Moreover, histopathological lesions including necrotizing nephritis was observed in the kidney of PDC-treated rats, while tubular epithelial degeneration and necrosis was observed in levonorgestrel-treated rats. Combined exposure to both compounds aggravated the increase in urea, creatinine and renal damage. Additionally, the antioxidant enzymes were further repressed in the co-treatment group. The study suggests that combined exposure to potassium dichromate and levonorgestrel worsened nephrotoxicity in rats by increasing oxidative stress.
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