Who is the Right Patient for Trans-Catheter Mitral Edge-to-Edge Repair?

Compare to surgical mitral valve intervention, trans-catheter mitral edge-to-edge repair show better procedural safety in patients with severe mitral regurgitation (MR). On the other hand, there is still a concern that more recurrent MR is observed in surgical eligible patients treated with Mitra Clip. As a result, trans-catheter mitral edge-to-edge repair is reserved for subjects with high or prohibitive surgical risk. In the real-world practice, majority of subjects with advanced age, severely depressed left ventricular systolic function, or in critical conditions are put in medical treatment alone rather than either surgical or trans-catheter mitral intervention. To improve the utilization of Mitra Clip in suitable patients, we will go through current evidence to identify the procedural safety and efficacy for trans-catheter mitral repair.