糖尿病黄斑水肿的光学相干断层扫描模式和贝伐单抗的治疗反应:一项短期研究

IF 2.3 Q2 OPHTHALMOLOGY
Sadhana Sharma, P. Karki, S. N. Joshi, S. Parajuli
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引用次数: 2

摘要

背景:本研究的目的是评估玻璃体内贝伐单抗治疗糖尿病黄斑水肿(DME)的短期反应,并使用光谱域-光学相干断层扫描(SD-OCT)评估不同形态模式下治疗结果的变化。目的:基于OCT研究DME的不同形态模式,并比较其对贝伐单抗的治疗效果。方法:纳入112例DME患者的112眼,用玻璃体内贝伐单抗(1.25 mg/0.05 ml,每月3次 月)。根据OCT将DME的形态学模式分为三组——弥漫性视网膜增厚(DRT)、囊状黄斑水肿(CME)和浆液性视网膜脱离(SRD)——并比较治疗后中心黄斑厚度(CMT)和最佳矫正视力(BCVA)的变化。结果:共有112眼DME患者,其中DRT 40眼,CME 37眼,SRD 35眼。贝伐单抗治疗导致三组中心黄斑厚度降低,BCVA改善。DRT组的基线视力和CMT均优于其他两组。根据CMT和BCVA测量治疗结果。CMT的变化在三组中具有统计学意义,DRT组的变化更好(p < 0.05、95%置信区间)。然而,在BCVA的变化方面,三组之间没有统计学上的显著差异(p = 0.169、95%置信区间)。结论:贝伐单抗可以改善所有类型DME的解剖和视觉。然而,个别模式可能会有不同的反应。DRT似乎是DME的最早形式,比其他类型的反应更好。因此,OCT显示的黄斑水肿模式可以为预测贝伐单抗注射液对DME的反应提供客观的指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optical coherence tomography patterns of diabetic macular edema and treatment response to bevacizumab: a short-term study
Background: The purpose of this study was to evaluate the short-term response of intravitreal bevacizumab in diabetic macular edema (DME) and assess the variation in treatment outcomes in different morphology patterns using spectral domain–optical coherence tomography (SD-OCT). Objective: To study different morphological patterns of DME based on OCT and compare their treatment response to bevacizumab. Methods: Hundred and twelve eyes of 112 patients with DME were included and treated with intravitreal bevacizumab (1.25 mg/0.05 ml monthly for 3 months). The morphological patterns of DME were classified on the basis of OCT into three groups – diffuse retinal thickening (DRT), cystoid macular edema (CME), and serous retinal detachment (SRD) – and changes in central macular thickness (CMT) and best corrected visual acuity (BCVA) after treatment were compared. Results: A total of 112 eyes with DME were included and consisted of 40 DRT, 37 CME, and 35 SRD. Treatment with bevacizumab resulted in decrease in central macular thickness and improvement in BCVA in all three groups. The baseline visual acuity and CMT of DRT group was better than that of the other two groups. The treatment outcome was measured in terms of CMT and BCVA. Change in CMT was statistically significant among three groups and was found to be better in DRT group (p < 0.05, 95% confidence interval). However, there was statistically no significant variation between the three groups regarding the change in BCVA (p = 0.169, 95% confidence interval). Conclusion: Anatomic and visual improvement can be achieved by bevacizumab in all patterns of DME. However, individual pattern may respond differently. DRT, which appears to be the earliest form of DME, responds better than other types. Thus, the pattern of macular edema shown by OCT may provide an objective guideline in predicting the response of bevacizumab injection in DME.
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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
44
审稿时长
12 weeks
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