受体变异和中枢作用药物的发展

IF 8.3 2区 医学 Q1 Medicine
S. Neale, K. Kambara, T. Salt, D. Bertrand
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引用次数: 1

摘要

在过去的10年里,在最大的制药公司和新兴的生物技术公司中观察到的研究范式的进步变化产生了对外包研究设施的需求。与此同时,基因组学、重组系统中的蛋白质表达和电生理记录方法等领域的进展为合同研究组织(cro)的发展提供了新的可能性。制药公司和cro之间的成功合作在很大程度上取决于所提供的能力和科学质量,以发现新的活性分子和靶标。因此,回顾神经科学研究领域的知识是至关重要的,遗传方法如何增加我们的知识,以及它们如何应用于从潜在分子的识别到第一次临床试验的转化。综上所述,很明显,cro在药物发现的神经科学中发挥着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Receptor variants and the development of centrally acting medications

The progressive changes in research paradigms observed in the largest pharmaceutical companies and the burgeoning of biotechnology startups over the last 10 years have generated a need for outsourcing research facilities. In parallel, progress made in the fields of genomics, protein expression in recombinant systems, and electrophysiological recording methods have offered new possibilities for the development of contract research organizations (CROs). Successful partnering between pharmaceutical companies and CROs largely depends upon the competences and scientific quality on offer for the discovery of novel active molecules and targets. Thus, it is critical to review the knowledge in the field of neuroscience research, how genetic approaches are augmenting our knowledge, and how they can be applied in the translation from the identification of potential molecules up to the first clinical trials. Taking these together, it is apparent that CROs have an important role to play in the neuroscience of drug discovery.

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来源期刊
Dialogues in Clinical Neuroscience
Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health
CiteScore
19.30
自引率
1.20%
发文量
1
期刊介绍: Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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