将呼吸道感染与抑郁症联系起来的新途径

IF 2.4 4区 医学 Q3 NEUROSCIENCES
Z. Karimi, Maryam Chenari, F. Rezaie, Shima Karimi, N. Parhizgari, T. Mokhtari-azad
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引用次数: 4

摘要

抑郁症是导致世界各地人们残疾和丧失有用生命的最重要原因之一。急性呼吸道感染在世界上造成了大量严重疾病和死亡,其中大多数是由病毒感染引起的,据估计,病毒感染占呼吸道感染的80%以上。通过免疫病原体识别受体检测病毒激活细胞内信号级联,并最终导致产生干扰素。炎症过程始于干扰素的分泌和干扰素刺激基因的表达。其中最重要的基因之一是吲哚胺吡咯2,3-双加氧酶(IDO),它在色氨酸分解代谢中起着重要作用。IDO是一种细胞内单体酶,在犬尿氨酸途径中也负责分解和消耗色氨酸。炎症增加与色氨酸浓度降低和犬尿氨酸水平升高有关。我们试图解释病毒性呼吸道感染引起的炎症在引起抑郁症中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Proposed Pathway Linking Respiratory Infections with Depression
Depression is one of the most important causes of disability and loss of useful life of people around the world. Acute respiratory infection caused a large number of severe illnesses and deaths of the world and most of these due to viral infections, which is estimated more than 80% of respiratory infections. Detection of viruses by immune pathogen recognition receptors activates the intracellular signaling cascade and eventually cause produces interferons. Inflammatory process begins with secretion of interferons and the expression of interferon-stimulated genes. One of the most important of these genes is indoleamine-pyrrole 2,3-dioxygenase (IDO), which plays a major role in tryptophan catabolism. IDO is an intracellular monomeric enzyme that is also responsible for breaking down and consuming tryptophan in the Kynurenine pathway. Increased inflammation has been linked to decrease tryptophan concentrations and increase kynurenine levels. We tried to explain the role of inflammation by viral respiratory infections in causing depression.
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来源期刊
Clinical Psychopharmacology and Neuroscience
Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY
CiteScore
4.70
自引率
12.50%
发文量
81
期刊介绍: Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.
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