肝移植供体保护的新进展

Q4 Medicine

中华肝胆外科杂志 Pub Date : 2019-11-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2019.11.019

Ning Zhang

{"title":"肝移植供体保护的新进展","authors":"Ning Zhang","doi":"10.3760/CMA.J.ISSN.1007-8118.2019.11.019","DOIUrl":null,"url":null,"abstract":"Liver transplantation is the unique effective life-saving procedure for patients suffering from end-stage liver diseases. The gap between the number of donor graft and patients in waiting lists dramatically increased and the shortage of donors becomes a severe challenge in liver transplantation. At present, the organ donation after death is the only source of organ transplantation in China. Ischemia-reperfusion injury significantly affects the quality of donor liver and the prognosis of recipient transplantation. Therefore, reasonable and effective organ protection techniques and strategies have received much concern in recent years. Here we reviewed the new progress in donor liver preservation and retrieval, surgical ischemia conditioning, drug intervention as well as gene therapy. \n \n \nKey words: \nLiver transplantation; Reperfusion injury; Donor protection","PeriodicalId":10021,"journal":{"name":"中华肝胆外科杂志","volume":"25 1","pages":"868-871"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New progress in donor protection for liver transplantation\",\"authors\":\"Ning Zhang\",\"doi\":\"10.3760/CMA.J.ISSN.1007-8118.2019.11.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Liver transplantation is the unique effective life-saving procedure for patients suffering from end-stage liver diseases. The gap between the number of donor graft and patients in waiting lists dramatically increased and the shortage of donors becomes a severe challenge in liver transplantation. At present, the organ donation after death is the only source of organ transplantation in China. Ischemia-reperfusion injury significantly affects the quality of donor liver and the prognosis of recipient transplantation. Therefore, reasonable and effective organ protection techniques and strategies have received much concern in recent years. Here we reviewed the new progress in donor liver preservation and retrieval, surgical ischemia conditioning, drug intervention as well as gene therapy. \\n \\n \\nKey words: \\nLiver transplantation; Reperfusion injury; Donor protection\",\"PeriodicalId\":10021,\"journal\":{\"name\":\"中华肝胆外科杂志\",\"volume\":\"25 1\",\"pages\":\"868-871\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华肝胆外科杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2019.11.019\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华肝胆外科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2019.11.019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

肝移植是治疗终末期肝病的唯一有效的挽救生命的方法。供体移植物的数量和等待名单上的患者之间的差距急剧增加，供体短缺成为肝移植的一个严重挑战。目前，死亡后的器官捐献是中国器官移植的唯一来源。缺血再灌注损伤严重影响供肝质量和受体移植的预后。因此，合理有效的器官保护技术和策略近年来备受关注。本文综述了供肝保存和修复、手术缺血预处理、药物干预以及基因治疗等方面的最新进展。关键词：肝移植；再灌注损伤；捐助者保护

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

New progress in donor protection for liver transplantation

Liver transplantation is the unique effective life-saving procedure for patients suffering from end-stage liver diseases. The gap between the number of donor graft and patients in waiting lists dramatically increased and the shortage of donors becomes a severe challenge in liver transplantation. At present, the organ donation after death is the only source of organ transplantation in China. Ischemia-reperfusion injury significantly affects the quality of donor liver and the prognosis of recipient transplantation. Therefore, reasonable and effective organ protection techniques and strategies have received much concern in recent years. Here we reviewed the new progress in donor liver preservation and retrieval, surgical ischemia conditioning, drug intervention as well as gene therapy. Key words: Liver transplantation; Reperfusion injury; Donor protection

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.