犬乳腺肿瘤中e -钙粘蛋白和p -钙粘蛋白表达改变对预后的影响

Q4 Veterinary

Brazilian Journal of Veterinary Pathology Pub Date : 2021-11-01 DOI:10.24070/bjvp.1983-0246.v14i3p145-150

L. Gomes, Ê. Ferreira, I. Oliveira, C. Campos, H. Gobbi, G. Cassali

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引用次数: 0

摘要

钙粘蛋白的表达与上皮性肿瘤的发展和侵袭性有关，然而，在犬乳腺肿瘤中，其对预后的意义尚不确定。因此，我们分析了25例犬乳腺肿瘤细胞内粘附分子E和P-cadherin的表达及其与总生存率的关系。E-cadherin表达减少与组织学类型、高组织学分级和总生存率相关。P-cadherin染色在恶性肿瘤中较高，与其他侵袭性临床病理特征无关。本研究的结果表明，在犬乳腺肿瘤中，E和p -钙粘蛋白的低表达与预后不良有关，包括总生存期缩短。

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Prognostic impact of alterations in E-cadherin and P-cadherin expression in canine mammary tumors

Expression of cadherins has been correlated to the development and aggressiveness of epithelial neoplasms, however, in canine mammary tumors, their significance prognostic is uncertain. Due to this fact, the expression of the intracellular adhesion molecules E and P-cadherin and correlation with overall survival were analyzed in 25 canine mammary gland tumors. E-cadherin expression reduction was correlated with histological type, high histological grade, and overall survival rate. P-cadherin staining was higher in malignant tumors, unrelated to other clinicopathological features of aggressiveness. The results of this study suggest a relationship between lower expression of E and P-cadherin and worse prognostic in canine mammary tumors, including shorter overall survival.

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来源期刊

Brazilian Journal of Veterinary Pathology Veterinary-Veterinary (miscellaneous)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The Brazilian Journal of Veterinary Pathology is the official electronic periodical of the Brazilian Association of Veterinary Pathology. The purpose of the BJVP is to publish original full papers, short communications, case reports, letters, reviews (by invited experts) and abstracts of scientific meetings. The preferable subjects is natural and experimental pathology. All the articles are submitted to scientific reviewers.