沙特阿拉伯Al-Ahsa地区机械通气新冠肺炎患者的特征：一项具有生存分析的回顾性研究

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Annals of Saudi Medicine Pub Date : 2022-05-01 DOI:10.5144/0256-4947.2022.165

A. Alamer, S. M. Asdaq, M. Alyamani, Hussain Alghadeer, Zahra H Alnasser, Zainab G. Aljassim, Maryam Albattat, A. Alhajji, Ahmed A. Alrashed, Y. Mozari, Abrar Aledrees, Badr Almuhainy, Ivo Abraham, Ahmad A Alamer

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引用次数: 1

摘要

背景：约5-10%的2019冠状病毒病（新冠肺炎）感染患者需要重症监护住院治疗和各种呼吸支持，包括有创机械通气。沙特阿拉伯的几项全国性研究已经确定了常见的合并症，但没有一项研究集中在沙特阿拉伯阿尔阿赫萨地区的机械通气患者身上。目的：确定机械通气新冠肺炎患者的死亡特征和危险因素。设计：回顾性图表回顾设置：沙特阿拉伯阿尔阿赫萨地区的两家综合医院患者和方法：我们纳入了2020年5月1日至11月30日期间在沙特阿拉伯阿尔阿赫萨地区两家主要综合医院入院的机械通气新冠肺炎患者（>18岁）。描述性统计被用来描述患者的特征。探索性地使用多变量Cox比例风险（CPH）模型来确定死亡率预测因子的风险比（HR）。主要观察指标：患者特点、死亡率、拔管率、是否需要重新插管以及住院期间的临床并发症。样本量和特征：154名机械通气新冠肺炎患者，中位（四分位间距）年龄为60（22）岁；65.6%为男性。结果：常见的合并症为糖尿病（72.2%）、高血压（67%）、心血管疾病（14.9%）和慢性肾脏疾病（CKD）（14.3%）。在多变量CPH模型中，年龄>60岁（HR=1.83，95%CI 1.2-2.7，P=0.002）、CKD（1.61，95%CI 0.9-2.6，P=.062）、胰岛素使用（HR=0.65，95%CI 0.35-0.08，P<.001），以及使用环状利尿剂（HR=0.51，95%CI 0.4，P=.037）是死亡率的主要预测因素。结论：在这项探索性分析中，来自Al-Ahsa地区的机械通气新冠肺炎患者的常见疾病是糖尿病、高血压、其他心血管疾病和CKD。局限性：回顾性，CPH模型性能较弱。利益冲突：无。

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Characteristics of mechanically ventilated COVID-19 patients in the Al-Ahsa Region of Saudi Arabia: a retrospective study with survival analysis

BACKGROUND: About 5-10% of coronavirus disease 2019 (COVID-19) infected patients require critical care hospitalization and a variety of respiratory support, including invasive mechanical ventilation. Several nationwide studies from Saudi Arabia have identified common comorbidities but none were focused on mechanically ventilated patients in the Al-Ahsa region of Saudi Arabia. OBJECTIVES: Identify characteristics and risk factors for mortality in mechanically ventilated COVID-19 patients. DESIGN: Retrospective chart review SETTING: Two general hospitals in the Al-Ahsa region of Saudi Arabia PATIENTS AND METHODS: We included mechanically ventilated COVID-19 patients (>18 years old) admitted between 1 May and 30 November 2020, in two major general hospitals in the Al-Ahsa region, Saudi Arabia. Descriptive statistics were used to characterize patients. A multivariable Cox proportional hazards (CPH) model was used exploratively to identify hazard ratios (HR) of predictors of mortality. MAIN OUTCOME MEASURES: Patient characteristics, mortality rate, extubation rate, the need for re-intubation and clinical complications during hospitalization. SAMPLE SIZE AND CHARACTERISTICS: 154 mechanically ventilated COVID-19 patients with median (interquartile range) age of 60 (22) years; 65.6% male. RESULTS: Common comorbidities were diabetes (72.2%), hypertension (67%), cardiovascular disease (14.9%) and chronic kidney disease (CKD) (14.3%). In the multivariable CPH model, age >60 years old (HR=1.83, 95% CI 1.2-2.7, P=.002), CKD (1.61, 95% CI 0.9-2.6, P=.062), insulin use (HR=0.65, 95% CI 0.35-.08, P<.001), and use of loop diuretics (HR=0.51, 95% CI 0.4, P=.037) were major predictors of mortality. CONCLUSION: Common diseases in mechanically ventilated COVID-19 patients from the Al-Ahsa region were diabetes, hypertension, other cardiovascular diseases, and CKD in this exploratory analysis. LIMITATIONS: Retrospective, weak CPH model performance. CONFLICTS OF INTEREST: None.

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来源期刊

Annals of Saudi Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Annals of Saudi Medicine (ASM) is published bimonthly by King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. We publish scientific reports of clinical interest in English. All submissions are subject to peer review by the editorial board and by reviewers in appropriate specialties. The journal will consider for publication manuscripts from any part of the world, but particularly reports that would be of interest to readers in the Middle East or other parts of Asia and Africa. Please go to the Author Resource Center for additional information.