用于癌症细胞检测的氮化硅光子生物传感器的设计和体灵敏度分析

IF 1.8 4区物理与天体物理 Q3 OPTICS

International Journal of Optics Pub Date : 2022-05-25 DOI:10.1155/2022/6085833

P. S., Sivabramanian A.

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引用次数: 4

摘要

体感度是验证光子波导传感器效率的一个重要参数。由于护理点硅光子生物传感的最新进展，重点是确定提高灵敏度的有效方法。在传感器结构中集成聚二甲基硅氧烷（PDMS）微流体通道会由于边缘分子的泄漏而降低灵敏度。氮化硅（SiN4）马赫-曾德干涉仪利用不同癌症细胞的折射率（1.39–1.401）来确定体积灵敏度。970的梯度阶梯肋槽结构 nm宽和400 nm厚度被设计成在没有任何PDMS材料的情况下保持液体样品。与梯度肋波导相比，这种新型波导表现出高的波导体灵敏度SW、体和器件体灵敏度SD。我们实现了波导体积灵敏度S w，体积为2.0699 RIU/RIU，器件灵敏度S d为568 通过时域有限差分（FDTD）分析。

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Design and Bulk Sensitivity Analysis of a Silicon Nitride Photonic Biosensor for Cancer Cell Detection

Bulk sensitivity is an important parameter to validate the efficiency of the photonic waveguide sensor. Due to recent advancements in point-of-care silicon photonic biosensing, the focus is to identify the effective way to improve sensitivity. Integrating polydimethylsiloxane (PDMS) microfluidic channel in sensor architecture decreases the sensitivity due to leakage of molecules at edges. The silicon nitride (SiN4) Mach–Zehnder interferometer utilizes the refractive index of different cancer cells (1.39–1.401) to determine the bulk sensitivity. The proposed gradient step rib-slot structure of 970 nm wide and 400 nm thickness is designed to hold the liquid sample without any PDMS material. This novel waveguide exhibits high waveguide bulk sensitivity S w , bulk and device bulk sensitivity S d compared with the gradient rib waveguide. We achieved a waveguide bulk sensitivity S w , bulk of 2.0699 RIU/RIU and device sensitivity S d of 568 nm/RIU through finite-difference time-domain (FDTD) analysis.

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来源期刊

International Journal of Optics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

13 weeks

期刊介绍： International Journal of Optics publishes papers on the nature of light, its properties and behaviours, and its interaction with matter. The journal considers both fundamental and highly applied studies, especially those that promise technological solutions for the next generation of systems and devices. As well as original research, International Journal of Optics also publishes focused review articles that examine the state of the art, identify emerging trends, and suggest future directions for developing fields.