社论

IF 1.1 Q3 EDUCATION & EDUCATIONAL RESEARCH
T. Allen
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BC surveillance in women with PHTS is effective because it contributes to the detection of early-stage BCs. 2 show that phase 3 trials comparing adjuvant therapies to observation are at risk for informative censoring that could potentially impact interpretation of study results. according to the most relevant prognostic features could better defi ne the biological behavior of the disease and thus allow better tailoring of adjuvant treatment. Human papillomavirus (HPV)-positive nasopharyngeal carcinoma (NPC) and Epstein–Barr virus (EBV)-positive NPC seem to be mutually exclusive diseases, and p16/HPV testing is helpful in EBV-negative NPC to elucidate potential viral etiology. HPV-positive NPC presents with a greater local symptom burden compared with EBV-positive NPC and HPV-positive oropharyngeal carcinoma, but outcomes are similar. Presence of TP53 mutations in acute myeloid leukemia (AML) are associated with an inferior outcome after an allogeneic stem cell transplant. This data demonstrates inferior overall survival post allograft in TP53 mutant AML is seen only in the presence of chromosome 17p loss or complex karyotype. In the absence of prospective data, this retrospective analysis of fi rst-line cytotoxic chemotherapy in advanced intra-abdominal well-differentiated/dedifferentiated liposarcoma (WDLPS) confi rms marginal activity of anthracycline monotherapy (overall response rate [ORR], 6%; median progression-free survival [m-PFS], 4 months), whereas doxorubicin-ifosfamide appeared more active (but not statistically signifi cant; ORR, 22%; m-PFS, 12 months). This retrospective study provides a benchmark for future trials on new drugs in WDLPS. conduct the Linxian Dysplasia Nutrition Intervention Trial. The purpose of this report is to update the results of this randomized, double-blind, placebo-controlled trial after nearly 35 years of follow-up and provide evidence for the effect of multivitamin supplementation on health. This report is the fi rst clinical trial to describe the use of a poly(ADP-ribose) polymerase inhibitor as monotherapy in children. Olaparib was well tolerated, with preliminary antitumor responses observed in DNA damage response–defective pediatric tumors. The authors present results from a validation study of an innovative pharmacogenomic tool to predict effective chemotherapeutic drug therapy for patients with advanced pancreatic cancer based on profi ling of circulating tumor and invasive cells isolated from peripheral blood. Results show that a simple blood test can guide an individualized approach to treating pancreatic cancer, leading to improved survival across the two standard frontline chemotherapy regimens. Although high-risk neuroblastoma patients with poor end-induction response are commonly treated with bridge therapy before consolidation with autologous stem cell transplantation (ASCT), the effi cacy of this approach has not been evaluated. 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引用次数: 0

摘要

von Hippel-Lindau的专家和患者开发了一种用于von Hipel-Lindau管理的临床护理途径。在这项回顾性队列研究中,纳入了65名患有PTEN错构瘤肿瘤综合征(PHTS)的女性,其中39人参加了乳腺癌症(BC)监测计划,并接受了年度乳腺磁共振成像和乳房X光检查。BC监测的绩效指标是充分的,癌症检测率很高(45/1000轮),与监测外检测到的BC相比,在监测期间检测到的BCs更多地处于早期阶段。PHTS妇女的BC监测是有效的,因为它有助于早期BC的检测。2表明,将辅助治疗与观察进行比较的3期试验存在信息审查的风险,这可能会影响对研究结果的解释。根据最相关的预后特征可以更好地定义疾病的生物学行为,从而更好地调整辅助治疗。人乳头瘤病毒(HPV)阳性的鼻咽癌(NPC)和EB病毒(EBV)阳性的NPC似乎是相互排斥的疾病,p16/HPV检测有助于EBV阴性的NPC阐明潜在的病毒病因。与EBV阳性NPC和HPV阳性口咽癌相比,HPV阳性NPC表现出更大的局部症状负担,但结果相似。急性髓系白血病(AML)中TP53突变的存在与异基因干细胞移植后的不良结果有关。该数据表明,只有在染色体17p缺失或复杂核型的情况下,TP53突变型AML的移植物后总生存率较低。在缺乏前瞻性数据的情况下,这项对晚期腹腔内高分化/去分化脂肪肉瘤(WDLPS)一线细胞毒性化疗的回顾性分析证实了蒽环类药物单药治疗的边际活性(总有效率[ORR],6%;中位无进展生存期[m-PFS],4个月),而多柔比星异环磷酰胺似乎更具活性(但无统计学意义;ORR,22%;m-PFS,12个月)。这项回顾性研究为未来WDLPS新药试验提供了一个基准。开展临县发育不良营养干预试验。本报告的目的是更新经过近35年随访的这项随机、双盲、安慰剂对照试验的结果,并为补充多种维生素对健康的影响提供证据。本报告是首次描述在儿童中使用聚ADP核糖聚合酶抑制剂作为单一疗法的临床试验。奥拉帕尼耐受性良好,在DNA损伤反应-缺陷儿童肿瘤中观察到初步的抗肿瘤反应。作者介绍了一项创新药物基因组工具的验证研究结果,该工具基于循环肿瘤和从外周血中分离的侵袭细胞的分布,预测晚期癌症患者的有效化疗药物治疗。结果表明,简单的血液检测可以指导癌症的个体化治疗方法,从而提高两种标准一线化疗方案的生存率。尽管末端诱导反应不佳的高危神经母细胞瘤患者通常在自体干细胞移植(ASCT)巩固前接受桥接治疗,但这种方法的有效性尚未得到评估。在这项回顾性多机构研究中,与直接接受ASCT的患者相比,接受桥接治疗的转移部位终末诱导稳定疾病患者的无事件生存率(EFS)显著提高,并且与残留转移性疾病的患者相比,在诱导治疗后具有完全转移反应但未进行ASCT的患者具有显著更好的3年EFS。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Editorial
A clinical care pathway for von Hippel–Lindau management has been developed by von Hippel–Lindau experts and patients. In this retrospective cohort study, 65 women with PTEN Hamartoma Tumor Syndrome (PHTS) were included, of which 39 were enrolled in the breast cancer (BC) surveillance program and underwent annual breast magnetic resonance imaging and mammography. Performance measures of BC surveillance were adequate, the cancer detection rate was high (45/1000 rounds), and BCs detected during surveillance were more often early stage compared with BCs detected outside surveillance. BC surveillance in women with PHTS is effective because it contributes to the detection of early-stage BCs. 2 show that phase 3 trials comparing adjuvant therapies to observation are at risk for informative censoring that could potentially impact interpretation of study results. according to the most relevant prognostic features could better defi ne the biological behavior of the disease and thus allow better tailoring of adjuvant treatment. Human papillomavirus (HPV)-positive nasopharyngeal carcinoma (NPC) and Epstein–Barr virus (EBV)-positive NPC seem to be mutually exclusive diseases, and p16/HPV testing is helpful in EBV-negative NPC to elucidate potential viral etiology. HPV-positive NPC presents with a greater local symptom burden compared with EBV-positive NPC and HPV-positive oropharyngeal carcinoma, but outcomes are similar. Presence of TP53 mutations in acute myeloid leukemia (AML) are associated with an inferior outcome after an allogeneic stem cell transplant. This data demonstrates inferior overall survival post allograft in TP53 mutant AML is seen only in the presence of chromosome 17p loss or complex karyotype. In the absence of prospective data, this retrospective analysis of fi rst-line cytotoxic chemotherapy in advanced intra-abdominal well-differentiated/dedifferentiated liposarcoma (WDLPS) confi rms marginal activity of anthracycline monotherapy (overall response rate [ORR], 6%; median progression-free survival [m-PFS], 4 months), whereas doxorubicin-ifosfamide appeared more active (but not statistically signifi cant; ORR, 22%; m-PFS, 12 months). This retrospective study provides a benchmark for future trials on new drugs in WDLPS. conduct the Linxian Dysplasia Nutrition Intervention Trial. The purpose of this report is to update the results of this randomized, double-blind, placebo-controlled trial after nearly 35 years of follow-up and provide evidence for the effect of multivitamin supplementation on health. This report is the fi rst clinical trial to describe the use of a poly(ADP-ribose) polymerase inhibitor as monotherapy in children. Olaparib was well tolerated, with preliminary antitumor responses observed in DNA damage response–defective pediatric tumors. The authors present results from a validation study of an innovative pharmacogenomic tool to predict effective chemotherapeutic drug therapy for patients with advanced pancreatic cancer based on profi ling of circulating tumor and invasive cells isolated from peripheral blood. Results show that a simple blood test can guide an individualized approach to treating pancreatic cancer, leading to improved survival across the two standard frontline chemotherapy regimens. Although high-risk neuroblastoma patients with poor end-induction response are commonly treated with bridge therapy before consolidation with autologous stem cell transplantation (ASCT), the effi cacy of this approach has not been evaluated. In this retrospective, multi-institutional study, patients with end-induction stable disease at metastatic sites who received bridge therapy had signifi cantly improved event-free survival (EFS) in comparison with those who directly underwent ASCT, and patients with a complete metastatic response after post-induction therapy who did not undergo ASCT had signifi cantly better 3-year EFS in comparison with those with residual metastatic disease.
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来源期刊
Improving Schools
Improving Schools EDUCATION & EDUCATIONAL RESEARCH-
CiteScore
5.50
自引率
0.00%
发文量
4
期刊介绍: Improving Schools is for all those engaged in school development, whether improving schools in difficulty or making successful schools even better. The journal includes contributions from across the world with an increasingly international readership including teachers, heads, academics, education authority staff, inspectors and consultants. Improving Schools has created a forum for the exchange of ideas and experiences. Major national policies and initiatives have been evaluated, to share good practice and to highlight problems. The journal also reports on visits to successful schools in diverse contexts, and includes book reviews on a wide range of developmental issues.
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