神经元中的自噬。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Andrea K H Stavoe, Erika L F Holzbaur
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引用次数: 0

摘要

自噬是细胞降解功能失调细胞器和蛋白质聚集体的主要途径。自噬在神经元中尤为重要,神经元是终末分化的细胞,必须持续整个生物体的生命周期。神经元自噬有构成性和应激诱导两种途径,可催化老化或受损的线粒体、内质网、其他细胞器和聚集蛋白的更新。这些通路在神经发育和维持神经元稳态中都是必需的。在此,我们综述了自噬体生物发生途径的核心成分,以及神经元中大量和选择性自噬的细胞生物学。最后,我们讨论了自噬在神经元发育、稳态和衰老中的作用,以及自噬缺陷与神经变性之间的联系。《细胞与发育生物学年度评论》第35卷的最终在线出版日期预计为2019年10月7日。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autophagy in Neurons.

Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. Autophagy is particularly important in neurons, which are terminally differentiated cells that must last the lifetime of the organism. There are both constitutive and stress-induced pathways for autophagy in neurons, which catalyze the turnover of aged or damaged mitochondria, endoplasmic reticulum, other cellular organelles, and aggregated proteins. These pathways are required in neurodevelopment as well as in the maintenance of neuronal homeostasis. Here we review the core components of the pathway for autophagosome biogenesis, as well as the cell biology of bulk and selective autophagy in neurons. Finally, we discuss the role of autophagy in neuronal development, homeostasis, and aging and the links between deficits in autophagy and neurodegeneration.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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