2型糖尿病患者的脂肪干细胞及其微环境

Q1 Biochemistry, Genetics and Molecular Biology

Stem cell investigation Pub Date : 2020-02-19 DOI:10.21037/sci.2019.12.02

Karina, J. Pawitan, I. Rosadi

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引用次数: 4

摘要

全球2型糖尿病(T2DM)患者数量持续上升。基质血管组分(SVF)含有脂肪组织干细胞(ASCs)，是一种治疗T2DM的替代疗法。T2DM通过升高血糖水平、氧化应激和缺氧来改变脂肪组织微环境(生态位)，从而增加炎症的危险因素，导致微环境(生态位)的重塑，从而可能影响脂肪组织中的各种细胞，包括ASCs。因此，糖尿病可能通过其微环境影响自体SVF的质量。在这篇综述中，我们讨论了脂肪组织的主要功能，包括脂肪形成、ASCs微环境和SVF在T2DM中的作用。

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Adipose-derived stem cells and their microenvironment (Niche) in type 2 diabetes mellitus

The number of type-2 diabetes mellitus (T2DM) is continuously rising globally. Stromal vascular fraction (SVF), which contains adipose tissue stem cells (ASCs), is an alternative therapy that is developed to overcome T2DM. T2DM changes adipose tissue microenvironment (niche) by increasing blood glucose level, oxidative stress and hypoxia, which increase the risk factors of inflammation that leads to remodelling of microenvironment (niche) that may have an impact on various cells in adipose tissue, including ASCs. Therefore, autologous SVF quality might be influenced by diabetes condition through its microenvironment. In this review, we addressed the main function of adipose tissue that includes adipogenesis, microenvironment of ASCs, and SVF in T2DM.

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来源期刊

Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

5.80

自引率

0.00%

发文量

期刊介绍： The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.