{"title":"人工冬虫夏草化学成分及其对纤维化的影响","authors":"Zhonghua Dong , Xiao Sun","doi":"10.1016/j.chmed.2022.11.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Cultivated <em>Cordyceps sinensis</em> powder has been used as clinical drug and healthy food to nourish the lung and kidney, which solves the problem of serious shortage of wild <em>C. sinensis</em>. This study aims to explore the chemical components and compared their anti-fibrotic effects in cultivated <em>C. sinensis</em>.</p></div><div><h3>Methods</h3><p>Nucleosides, sterols and polysaccharides were separated and purified from cultivated <em>C. sinensis</em>, and analyzed by high performance liquid chromatography, gas chromatography-mass spectrometry and chemical chromogenic methods, respectively. In high glucose-induced rat mesangial cell models, fibronectin and type 1 collagen were used as evaluation indicators.</p></div><div><h3>Results</h3><p>There were 10 kinds of nucleosides and one sterol in cultivated <em>C. sinensis</em>. The contents of nucleosides, sterols and polysaccharides in the cultivated <em>C. sinensis</em> were close to 2%, 0.55% and 4.4%, respectively. Furthermore, nucleoside, sterol and polysaccharide components exhibited varying degrees of anti-fibrotic activity. The nucleoside components and sterol components inhibited the expression of extracellular matrix more effectively in the three main components.</p></div><div><h3>Conclusion</h3><p>Cultivated <em>C. sinensis</em> remains the similar compounds with the wild <em>C. sinensis</em>, and nucleosides and sterols may be the main active substances that contribute to its anti-fibrotic effects. The project of this study may provide valuable information on further optimization of more effective remedies with few side effects based on cultivated <em>C. sinensis</em>.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 1","pages":"Pages 162-167"},"PeriodicalIF":4.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000552/pdfft?md5=319177d3f4deaee59ed069f7d56fc30b&pid=1-s2.0-S1674638423000552-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis\",\"authors\":\"Zhonghua Dong , Xiao Sun\",\"doi\":\"10.1016/j.chmed.2022.11.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Cultivated <em>Cordyceps sinensis</em> powder has been used as clinical drug and healthy food to nourish the lung and kidney, which solves the problem of serious shortage of wild <em>C. sinensis</em>. This study aims to explore the chemical components and compared their anti-fibrotic effects in cultivated <em>C. sinensis</em>.</p></div><div><h3>Methods</h3><p>Nucleosides, sterols and polysaccharides were separated and purified from cultivated <em>C. sinensis</em>, and analyzed by high performance liquid chromatography, gas chromatography-mass spectrometry and chemical chromogenic methods, respectively. In high glucose-induced rat mesangial cell models, fibronectin and type 1 collagen were used as evaluation indicators.</p></div><div><h3>Results</h3><p>There were 10 kinds of nucleosides and one sterol in cultivated <em>C. sinensis</em>. The contents of nucleosides, sterols and polysaccharides in the cultivated <em>C. sinensis</em> were close to 2%, 0.55% and 4.4%, respectively. Furthermore, nucleoside, sterol and polysaccharide components exhibited varying degrees of anti-fibrotic activity. The nucleoside components and sterol components inhibited the expression of extracellular matrix more effectively in the three main components.</p></div><div><h3>Conclusion</h3><p>Cultivated <em>C. sinensis</em> remains the similar compounds with the wild <em>C. sinensis</em>, and nucleosides and sterols may be the main active substances that contribute to its anti-fibrotic effects. The project of this study may provide valuable information on further optimization of more effective remedies with few side effects based on cultivated <em>C. sinensis</em>.</p></div>\",\"PeriodicalId\":9916,\"journal\":{\"name\":\"Chinese Herbal Medicines\",\"volume\":\"16 1\",\"pages\":\"Pages 162-167\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1674638423000552/pdfft?md5=319177d3f4deaee59ed069f7d56fc30b&pid=1-s2.0-S1674638423000552-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Herbal Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1674638423000552\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Herbal Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1674638423000552","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis
Objective
Cultivated Cordyceps sinensis powder has been used as clinical drug and healthy food to nourish the lung and kidney, which solves the problem of serious shortage of wild C. sinensis. This study aims to explore the chemical components and compared their anti-fibrotic effects in cultivated C. sinensis.
Methods
Nucleosides, sterols and polysaccharides were separated and purified from cultivated C. sinensis, and analyzed by high performance liquid chromatography, gas chromatography-mass spectrometry and chemical chromogenic methods, respectively. In high glucose-induced rat mesangial cell models, fibronectin and type 1 collagen were used as evaluation indicators.
Results
There were 10 kinds of nucleosides and one sterol in cultivated C. sinensis. The contents of nucleosides, sterols and polysaccharides in the cultivated C. sinensis were close to 2%, 0.55% and 4.4%, respectively. Furthermore, nucleoside, sterol and polysaccharide components exhibited varying degrees of anti-fibrotic activity. The nucleoside components and sterol components inhibited the expression of extracellular matrix more effectively in the three main components.
Conclusion
Cultivated C. sinensis remains the similar compounds with the wild C. sinensis, and nucleosides and sterols may be the main active substances that contribute to its anti-fibrotic effects. The project of this study may provide valuable information on further optimization of more effective remedies with few side effects based on cultivated C. sinensis.
期刊介绍：
Chinese Herbal Medicines is intended to disseminate the latest developments and research progress in traditional and herbal medical sciences to researchers, practitioners, academics and administrators worldwide in the field of traditional and herbal medicines. The journal's international coverage ensures that research and progress from all regions of the world are widely included.
CHM is a core journal of Chinese science and technology. The journal entered into the ESCI database in 2017, and then was included in PMC, Scopus and other important international search systems. In 2019, CHM was successfully selected for the “China Science and Technology Journal Excellence Action Plan” project, which has markedly improved its international influence and industry popularity. CHM obtained the first impact factor of 3.8 in Journal Citation Reports (JCR) in 2023.
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