博来霉素致Flagellate皮炎1例

Serbian Journal of Dermatology and Venereology Pub Date : 2020-03-01 DOI:10.2478/sjdv-2020-0003

B. Tonin, D. Geat, G. Girolomoni

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引用次数: 0

摘要

鞭毛状皮炎是一种独特的皮肤疹，与多种原因有关，包括使用某些化疗药物治疗，摄入毒素和风湿病，如成人发病的斯蒂尔氏病和皮肌炎。我们报告了一例35岁的IIA期霍奇金淋巴瘤患者，她接受了ABVD化疗方案(阿霉素、博来霉素、长春碱和达卡巴嗪)的治疗。在化疗的第三个周期中，患者出现多发线状红斑和显著的鞭毛样色素沉着，分布于胸部上部、乳腺下褶皱、颈部和背部上部。病变在停用博来霉素后三个月内完全消退。临床医生应该意识到接受博来霉素联合化疗的患者这种独特的皮肤毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bleomycin-induced Flagellate Dermatitis: a Case Report

Abstract Flagellate dermatitis represents a unique cutaneous eruption associated with several causes, including treatment with certain chemotherapeutic agents, ingestion of toxins and rheumatologic conditions like adult-onset Still’s disease and dermatomyositis. We present the case of a 35-year-old woman with stage IIA Hodgkin lymphoma who was treated with the ABVD chemotherapy regimen (doxorubicin, bleomycin, vinblastine and dacarbazine). During the third cycle of chemotherapy, she developed multiple linear erythematous macules and hyperpigmentation in a striking flagellate-like pattern localized on the upper chest, submammary folds, neck and upper part of the back. The lesions resolved completely within three months after the withdrawal of bleomycin. Clinicians should be aware of this distinctive cutaneous toxicity in patients receiving bleomycin combination chemotherapy.

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来源期刊

Serbian Journal of Dermatology and Venereology

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期刊介绍： Serbian Journal of Dermatology and Venereology is a journal of the Serbian Association of Dermatologists and Venereologists. The journal is published in English, quarterly and intended to provide rapid publication of papers in the field of dermatology and venereology. Manuscripts are welcome from all countries in the following categories: editorials, original studies, review articles, professional articles, case reports, and history of medicine.