β受体阻滞剂治疗败血症的疗效

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2021-01-03 DOI:10.3329/BJP.V16I1.46001

Peng Jin, Ting Zhao, Yueyue Wei, Fang Zhao

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引用次数: 1

摘要

本荟萃分析旨在系统评价β受体阻滞剂治疗败血症的疗效和安全性。共纳入17篇符合纳入标准的文章，获得10385例。荟萃分析结果显示，使用β受体阻滞剂的败血症患者28天死亡率显著降低。使用β受体阻滞剂的败血症患者的心率随着时间的推移而下降。此外，中心静脉血氧饱和度在治疗24、48、72小时后增加；乳酸和心肌肌钙蛋白I在治疗48、72小时后降低；治疗12、24、48、72小时后，肿瘤坏死因子-α、白细胞介素-1β水平显著下降（p<0.05）。总之，β受体阻滞剂可降低28天死亡率和心率。

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Efficacy of beta-blockers in the treatment of sepsis

This meta-analysis is to systematically evaluate the efficacy and safety of beta-blockers in the treatment of sepsis. A total of 17 articles that met the inclusion criteria were included, and 10,385 cases were obtained. The meta-analysis results showed that patients with sepsis with beta-blocker usage had a significantly lower 28-day mortality. The heart rate decreased over time in patients with sepsis using beta-blocker. Moreover, central venous blood oxygen saturation increased after 24, 48, 72 hours of treatment; lactic acid and cardiac troponin I decreased after 48, 72 hours of treatment; and tumor necrosis factor-α, interleukin-1β levels decreased significantly after 12, 24, 48, 72 hours of treatment (p<0.05). In conclusion, beta-blockers reduce 28-day mortality and heart rate.

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.