Physalin A促进糖尿病肾病的自噬，抑制氧化应激损伤和细胞外基质沉积

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-04-07 DOI:10.37290/ctnr2641-452x.21:131-137

Miao Zhang, Dan-dan Huang, Dan Chen, Taotao Hu

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引用次数: 0

摘要

糖尿病肾病是世界范围内慢性肾脏疾病的主要病因。持续性高血糖在糖尿病肾病中起致病作用。Physalin A是一种甾体植物衍生的生物活性化合物，具有抗炎、抗肿瘤、抗真菌和镇痛活性，已广泛应用于中药实践。本研究检测了藻盐A对高糖处理的糖尿病肾病细胞培养模型HBZY-1细胞的影响。结果表明，藻盐蛋白A通过抑制丝裂原活化蛋白激酶途径，减轻高糖诱导的细胞增殖、氧化应激、细胞外基质蛋白沉积和自噬不足。

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Physalin A Enhances Autophagy and Suppresses Oxidative Stress Injury and Extracellular Matrix Deposition in Diabetic Nephropathy

Diabetic nephropathy is the major cause of chronic kidney disease worldwide. Persistent hyperglycemia plays a causative role in diabetic nephropathy. Physalin A, a steroidal plant-derived bioactive compound known to exhibit anti-inflammatory, anti-tumor, anti-fungal, and analgesic activities, has been widely used in traditional Chinese medicine practice. The present study examined the effect of Physalin A on high-glucose-treated HBZY-1 cells, a cell culture model of diabetic nephropathy. The results show that Physalin A alleviated cell proliferation, oxidative stress, extracellular matrix protein deposition, and insufficient autophagy induced by high glucose through inhibiting the mitogen-activated protein kinase pathway.

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.