性激素及其受体在肝脏脂质代谢中的作用机制研究进展

Q4 Medicine

中华内分泌代谢杂志 Pub Date : 2020-03-25 DOI:10.3760/CMA.J.CN311282-20190520-00190

Lu Liu, Yuyou Jiang, Shushu Li

{"title":"性激素及其受体在肝脏脂质代谢中的作用机制研究进展","authors":"Lu Liu, Yuyou Jiang, Shushu Li","doi":"10.3760/CMA.J.CN311282-20190520-00190","DOIUrl":null,"url":null,"abstract":"The liver is one of the most important organs which regulate lipid metabolism in the body. Hepatic steatosis is a major manifestation of metabolic syndrome and is associated with an imbalance between lipid synthesis and decomposition. There are gender and age differences in the prevalence of fatty liver, suggesting that sex hormones may play a crucial role. This review summarizes current literatures on the regulation of hepatic lipid metabolism by sex hormones and their receptors. In females, estradiol binds to estrogen receptors to reduce liver fat production and fatty acid intake, while enhancing lipolysis and cholesterol secretion. In males, testosterone reduces adipogenesis and promotes fat breakdown through androgen receptors. These findings suggest that sex hormones and their receptors can serve as potential targets for preventing hepatic steatosis. \n \n \nKey words: \nSex hormones; Estrogen receptor; Androgen receptor; Liver; Lipid metabolism","PeriodicalId":10120,"journal":{"name":"中华内分泌代谢杂志","volume":"36 1","pages":"267-272"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research progress on the mechanism of sex hormones and their receptors in liver lipid metabolism\",\"authors\":\"Lu Liu, Yuyou Jiang, Shushu Li\",\"doi\":\"10.3760/CMA.J.CN311282-20190520-00190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The liver is one of the most important organs which regulate lipid metabolism in the body. Hepatic steatosis is a major manifestation of metabolic syndrome and is associated with an imbalance between lipid synthesis and decomposition. There are gender and age differences in the prevalence of fatty liver, suggesting that sex hormones may play a crucial role. This review summarizes current literatures on the regulation of hepatic lipid metabolism by sex hormones and their receptors. In females, estradiol binds to estrogen receptors to reduce liver fat production and fatty acid intake, while enhancing lipolysis and cholesterol secretion. In males, testosterone reduces adipogenesis and promotes fat breakdown through androgen receptors. These findings suggest that sex hormones and their receptors can serve as potential targets for preventing hepatic steatosis. \\n \\n \\nKey words: \\nSex hormones; Estrogen receptor; Androgen receptor; Liver; Lipid metabolism\",\"PeriodicalId\":10120,\"journal\":{\"name\":\"中华内分泌代谢杂志\",\"volume\":\"36 1\",\"pages\":\"267-272\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华内分泌代谢杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.CN311282-20190520-00190\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华内分泌代谢杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.CN311282-20190520-00190","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

肝脏是调节机体脂质代谢的重要器官之一。肝脂肪变性是代谢综合征的主要表现，与脂质合成和分解失衡有关。脂肪肝的患病率存在性别和年龄差异，这表明性激素可能起着至关重要的作用。本文就性激素及其受体调控肝脏脂质代谢的研究进展进行综述。在女性中，雌二醇与雌激素受体结合，减少肝脏脂肪生成和脂肪酸摄入，同时促进脂肪分解和胆固醇分泌。在男性中，睾酮通过雄激素受体减少脂肪生成并促进脂肪分解。这些发现提示性激素及其受体可作为预防肝脂肪变性的潜在靶点。关键词:性激素;雌激素受体;雄激素受体;肝;脂质代谢

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Research progress on the mechanism of sex hormones and their receptors in liver lipid metabolism

The liver is one of the most important organs which regulate lipid metabolism in the body. Hepatic steatosis is a major manifestation of metabolic syndrome and is associated with an imbalance between lipid synthesis and decomposition. There are gender and age differences in the prevalence of fatty liver, suggesting that sex hormones may play a crucial role. This review summarizes current literatures on the regulation of hepatic lipid metabolism by sex hormones and their receptors. In females, estradiol binds to estrogen receptors to reduce liver fat production and fatty acid intake, while enhancing lipolysis and cholesterol secretion. In males, testosterone reduces adipogenesis and promotes fat breakdown through androgen receptors. These findings suggest that sex hormones and their receptors can serve as potential targets for preventing hepatic steatosis. Key words: Sex hormones; Estrogen receptor; Androgen receptor; Liver; Lipid metabolism

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华内分泌代谢杂志 Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

0.60

自引率

0.00%

发文量

7243

期刊介绍： The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.