“睾酮替代通过上调PPARα调节心肌梗死后心脏代谢重塑”的关注表达

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
PPAR Research Pub Date : 2019-06-11 DOI:10.1155/2019/5137020
PPAR Research
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引用次数: 0

摘要

PPAR Research对2016年6月发表在PPAR Research上的题为“睾酮替代通过上调PPARα调节心脏代谢重塑和心肌梗死”的文章[1]表示关注,因为文章质量存在缺陷。编辑委员会认为,由于缺少对照组,实验设计不够可靠。我认为这很令人困惑大多数数据集在图例中被标记为n=3这对于动物实验来说是非常低的。此外,董事会发现作者在方法中描述的每组数都不是n=3,而是略高。没有解释为什么不是所有的动物都被包括在所有的分析中,以及如何选择数据集。在一些数据集中,作者使用n=6,但一些动物数据集缺失。作者解释说,在材料和方法中,使用额外的正常大鼠进行相同的手术,没有LDA闭塞作为对照组。此外,在材料和方法中提到了心肌梗死后存活的动物数量,图中图例中的动物数量比材料和方法中少,因为剩余的存活大鼠被分成几个部分进行不同的实验。ey补充说,在超声心动图测量过程中,Cas组有2只大鼠因麻醉死亡,所以他们从不同的组中取了4只大鼠来评估心脏指标。在超声心动图研究中,除了收集血液和心脏样本外,还立即将大鼠处死。不同组的最小数量为6例(8例S-Cas, 6例Cas, 7例Cas+T, 6例Cas+T+F)。据此,他们测量了6只大鼠的ATP含量和性激素。其余3只采用western blotting和real-time PCR方法。e编委会对几只动物的死亡表示关注,作者应该清楚地说明,为什么在提到每种治疗时,n = 8, n为3-6。此外,委员会发现统计分析没有做得很好,他们建议重复研究以增加样本量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression of Concern on “Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα”
PPAR Research would like to express concern with the article titled “Testosterone Replacement Modulates Cardiac Metabolic Remodeling a erMyocardial Infarction by Upregulating PPARα” [1] published in PPAR Research in June 2016 due to flaws found in the quality of the article. eEditorial Board believed that the experimental design is not solid enough as the control groups are missing. ey thought that it is confusing that most of the data sets are labeled with n=3 in the legends which is extremely low for animal experiments. In addition, the board found that the authors described each group number in the methods which is not n=3 but slightly higher. ere is no explanation why not all animals were included in all analyses and how a selection of data sets was performed. In some data sets, the authors use n=6 but some animal data sets are missing. e authors explained that, in theMaterials andMethods, additional normal rats that underwent the same procedure without LDA occlusion were used as the control group. Moreover, the number of animals which were alive a er the myocardial infarction was mentioned in the Materials and Methods and the number of animals in figure legendswas less than that in theMaterials andMethods as the remaining alive rats were divided into several parts for different experiments. ey added that, during echocardiographic measurement, two rats of Cas group died from anesthesia, so they took four rats from different groups to evaluate cardiac indexes. A er echocardiographic studies, the rats were immediately executed in addition to collecting blood and heart samples. e minimum number of different groups was 6 (8 S-Cas, 6 Cas, 7 Cas+T, and 6 Cas+T+F). Accordingly, they measured ATP content and sexual hormones of six rats. ree rats were performed by histological analysis, and the other three were performed by western blotting and real-time PCR. e Editorial Board was concerned about the death of several animals which should be clearly defined by the authors as they should state why the n was 3-6 when each treatment is mentioned with an n = 8. Moreover, the board found that the statistical analysis was not done properly and they recommended repeating the study to increase the sample size.
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来源期刊
PPAR Research
PPAR Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.20
自引率
3.40%
发文量
17
审稿时长
12 months
期刊介绍: PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.
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