吲哚菁绿——有待探索的潜力:叙事回顾

IF 0.5 4区 医学 Q4 SURGERY
C. Bertani, E. Cassinotti, M. Porta, M. Pagani, L. Boni, L. Baldari
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引用次数: 4

摘要

目的:腹腔镜手术是治疗早期癌症的标准方法,但没有证据表明腹腔镜手术治疗晚期胃癌。微创技术会带来一些并发症,其中最令人担忧的是吻合口瘘。此外,这种方法的某些方面,如淋巴结切除术的扩展,仍存在争议。近年来,吲哚菁绿(ICG)荧光成像被引入腹腔镜手术,以改善解剖和病理结构的可视化。这篇综述文章的目的是深入探讨ICG成像在癌症手术中的所有可能应用。背景:注射后,ICG在被激光束或特定波长的近红外光激发时会变为荧光。ICG释放的荧光可以使用专门指定的示波器和相机进行检测。在癌症手术领域,ICG可以静脉注射,以显示动脉和肠灌注,或肿瘤周围,以显示肿瘤和淋巴结。方法:利用PubMed和Embase数据库进行文献检索,找出ICG荧光引导手术和腹腔镜癌症胃癌手术的相关文献。结论:与标准方法相比,本文更详细地显示了ICG荧光血管造影术的适应症及其与吻合口瘘的关系。然后,它定义了ICG用于进行前哨淋巴结标测的优势,并将其应用于早期癌症。使用ICG进行淋巴标测以进行淋巴结切除术是一种视觉指南,可以增加采集的淋巴结数量。最后,已经发表了关于ICG用于腹膜癌术中鉴定的实验研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Indocyanine green—a potential to explore: narrative review
Objective: Laparoscopic surgery is the standard approach for treatment of early stages of gastric cancer, as there is no evidence to recommend it in more advanced cancers. The minimally invasive technique is associated with some complications, the most concerning of which is anastomotic leakage. Moreover, some aspects of this approach, like lymphadenectomy extension, are still debated. In last years, indocyanine green (ICG) fluorescence imaging was introduced in laparoscopic surgery to improve visualization of anatomical and pathological structures. The purpose of this review article is to delve into all the possible applications of ICG imaging in gastric cancer surgery. Background: After injection, ICG becomes fluorescent when excited either by a laser beam, or by near-infrared light at certain wave lengths. The fluorescence released by ICG can be detected using specifically designated scopes and cameras. In the field of gastric cancer surgery, ICG can be injected intravenously, to visualize arteries and bowel perfusion, or peritumoral, to visualize the tumour and the lymph nodes. Methods: A literature search was performed using PubMed and Embase database to identify relevant articles on ICG fluorescence guided surgery and laparoscopic gastric cancer surgery. Conclusions: More in detail, the paper shows the indications of ICG fluorescence angiography and its association with anastomotic leakage, if compared to standard procedure. Then, it defines the advantages of ICG use to perform the sentinel lymph node mapping, with its application in early gastric cancer. The use of ICG for lymphatic mapping to perform lymphadenectomy is a visual guide and allows to increase the number of lymph nodes harvested. Finally, experimental studies have been published on the use of ICG for and intraoperative identification of peritoneal carcinomatosis.
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
20
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