生物金属（Ⅱ）莫能酸盐对大鼠Zajdela肝癌的体外毒性研究

IF 0.7 Q3 MULTIDISCIPLINARY SCIENCES

Chemistry-Didactics-Ecology-Metrology Pub Date : 2020-12-01 DOI:10.2478/cdem-2020-0009

R. Alexandrova, T. Zhivkova, D. Ivanov, Boika Andonova-Lilova, L. Dyakova, Ivayla N. Pantcheva, P. Dorkov

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引用次数: 1

摘要

摘要评价了莫能菌酸A（MonH∙H2O）及其与Mg2+、Ca2+、Mn2+、Co2+、Ni2+和Zn2+离子的中性金属络合物[M（Mon）2（H2O）2]降低原代细胞培养物的活力和增殖的能力，所述原代细胞源于化学诱导的大鼠Zajdela可移植肝肿瘤，以及来自相同肿瘤载体的骨髓细胞。实验数据显示，与健康骨髓细胞相比，莫能菌素A的锰（II）和镍（II）复合物对肿瘤的选择性相对更高。

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Study on in vitro Toxicity of Biometal(II) Monensinates Against Rat Zajdela Liver Tumour

Abstract The ability of Monensic acid A (MonH∙H2O) and its neutral metal complexes [M(Mon)2(H2O)2]with ions of Mg2+, Ca2+, Mn2+, Co2+, Ni2+ and Zn2+ to decrease viability and proliferation of primary cell cultures, originating from a chemically induced transplantable liver tumour of Zajdela in rats, and bone marrow cells from the same tumour-bearers, was evaluated. Experimental data revealed that manganese(II) and nickel(II) complexes of Monensin A are relatively more selective against the tumour as compared to the healthy bone marrow cells.

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来源期刊

Chemistry-Didactics-Ecology-Metrology MULTIDISCIPLINARY SCIENCES-

CiteScore

1.50

自引率

50.00%

发文量