感染急性期和慢性期多发性硬化症与幽门螺杆菌的相关性：系统综述和荟萃分析

Q4 Medicine

Romanian Journal of Neurology/ Revista Romana de Neurologie Pub Date : 2023-03-31 DOI:10.37897/rjn.2023.1.2

A. Bakhshi, A. Saberi, Naeim Norouzi, Nasrin Sedighi

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引用次数: 1

摘要

多发性硬化症是一种中枢神经系统脱髓鞘性自身免疫性疾病。它与几个因素有关，其中之一是幽门螺杆菌。提示HP在急性期和慢性期对MS可能有不同的影响；因此，我们评估了HP和MS在感染急性期和慢性期的相关性。Scopus、PubMed和Web of Science数据库用于系统搜索。最后，根据纳入标准，选择了8项研究。根据本研究的结果，MS与HP在病程和EDSS方面没有显著差异。汇总结果显示，平均EDSS的标准差为-0.910，平均持续时间的标准差是-0.067。此外，通过比较HP急性期和慢性期与对照组的抗体水平。最后，我们评估了感染两个阶段之间的平均EDSS，这表明急性期MS的平均EDSS和临床弱点略高于慢性期。总之，HP感染可以根据感染的发作和活动对免疫系统产生刺激或抑制作用。

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Association between multiple sclerosis and Helicobacter pylori in the acute and chronic phases of infection: A systematic review and meta-analysis

Multiple sclerosis is a demyelinating autoimmune disease in the central nervous system. It is associated with several factors, one of which is Helicobacter pylori. We suggested that HP may have different effects on MS in the acute and chronic phases; therefore, we evaluated the HP and MS association in acute and chronic phases of infection. Scopus, PubMed, and Web of Science databases were used for systematic search. Finally, according to the inclusion criteria, eight studies were selected. According to the result of this study, there was no significant difference in the disease duration and EDSS between MS with HP. Pooled results showed that the standard difference in the mean EDSS was - 0.910, and the standard difference in the mean duration was - 0.067. Also, by comparing antibody levels in the acute and chronic phases of HP with the control group. Finally, we evaluate the mean EDSS between the two phases of infection, which shows that the mean EDSS and the clinical weaknesses of MS in the acute phase were slightly higher than in the chronic. In conclusion, HP infection can have a stimulating or inhibiting effect on the immune system based on the onset and activity of the infection.

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来源期刊

Romanian Journal of Neurology/ Revista Romana de Neurologie Medicine-Neurology (clinical)

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ROMANIAN JOURNAL OF NEUROLOGY (Revista Română de Neurologie), the official journal of the Romanian Society of Neurology, was founded in 2001, being a prestigious scientific journal that provides a high quality in terms of scientific content, but also the editorial and graphic aspect, both through an impartial process of selection, evaluation and correction of articles (peer review procedure), as well as providing editorial, graphic and printing conditions at the highest level. In order to increase the scientific standards of the journal, special attention was paid to the improvement of the quality of the published materials. Guidance articles, clinical trials and case studies are structured in several sections: reviews, original articles, case reports, images in neurology. All articles are published entirely in English. A team of reputable medical professionals in the field of neurology is involved in a rigorous peer review process that complies with international ethics and quality rules in the academic world.