脂质过多和非酒精性脂肪肝引起的肝毒性的分子机制和介质

IF 0.9 Q4 GASTROENTEROLOGY & HEPATOLOGY
C. Finelli
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引用次数: 2

摘要

本文综述了一些涉及肝毒性的机制,这是由过量的脂质诱导的。本文涵盖了广泛的主题:从过量脂质的分子机制,到高脂血症的治疗,再到降脂药物的肝毒性。NAFLD目前是西方国家慢性肝病的主要原因;导致NAFLD的分子机制只被部分理解,也没有有效的治疗干预措施。在工业化国家,由于一些生活方式变量,包括过量的热量摄入、不平衡的饮食、缺乏身体活动和滥用肝毒性药物,肝病的患病率不断上升。考虑到细胞死亡和炎症在大多数(如果不是全部)肝脏疾病的病因学中的重要功能,一种有效的治疗方法可能包括单独或联合使用保肝和抗炎药物。临床试验目前正在不同肝病患者队列中进行,以探索这一理论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular Mechanisms and Mediators of Hepatotoxicity Resulting from an Excess of Lipids and Non-Alcoholic Fatty Liver Disease
The paper reviews some of the mechanisms implicated in hepatotoxicity, which is induced by an excess of lipids. The paper spans a wide variety of topics: from the molecular mechanisms of excess lipids, to the therapy of hyperlipidemia, to the hepatotoxicity of lipid-lowering drugs. NAFLD is currently the leading cause of chronic liver disease in Western countries; the molecular mechanisms leading to NAFLD are only partially understood and there are no effective therapeutic interventions. The prevalence of liver disease is constantly increasing in industrialized countries due to a number of lifestyle variables, including excessive caloric intake, unbalanced diet, lack of physical activity, and abuse of hepatotoxic medicines. Considering the important functions of cell death and inflammation in the etiology of the majority, if not all, liver diseases, one efficient therapeutic treatment may include the administration of hepatoprotective and anti-inflammatory drugs, either alone or in combination. Clinical trials are currently being conducted in cohorts of patients with different liver diseases in order to explore this theory.
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来源期刊
CiteScore
1.50
自引率
0.00%
发文量
0
审稿时长
10 weeks
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