A Review on the Nutraceutical Anti-Metastatic Importance of Annona Muricata Crude Extract (AMCE) and its Coping Mechanism Against Breast Cancer

Annona Muricata is used as a folkloric herbal medicine as it has anticancer, antiproliferative and anti-tumorigenic properties. The extracts from various parts of the plant are considered therapeutic due to Annonaceous Acetogenin compounds which are an absolute boon to the versatility of the plant, paving the mechanistic pathways for its therapeutic potential. Google Scholar and PubMed databases were reviewed with the main focus on availing information on Annona muricata and its anticancer effect on breast cancer. - An array of clinical investigations on the dosage of extracts on cell lines, animal models, and human trials provide confirmatory insights of A. muricata as a preventive and therapeutic measure for cancer. The extract when administered at different dosages shows a high cytotoxic effect on the cancer cells, mostly accounting for an IC50 of less than 1000µg/mL which is of significance. Although high efficacy has been conclusive, assurance of the safety prior to commercialization is of significance. Investigations are required to define the origin and magnitude of side effects along with long-term safety for the enhancement of efficacy and optimum utilization of potential chemo-preventive properties of the plant for the curation of a nutraceutical intervention for cancer that surpasses the traditional medicine.