核酸适体:靶向SARS-CoV-2的新见解

Suna Karadeniz Saygılı, A. Szymanowska, G. Lopez-Berestein, Cristian Rodríguez-Aguayo, P. Amero
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引用次数: 1

摘要

严重急性呼吸综合征冠状病毒(SARS-CoV-2)仍然是世界上高死亡率的一个主要原因。尽管许多治疗方法已经成功开发,仍然需要找到新的和更有效的治疗策略来面对即将到来的变异。在这里,我们将描述适配体的潜在用途,合成单链寡核苷酸,作为靶向SARS-CoV-2的有前途的工具。由于核酸适体已经成功地开发出了针对病毒的核酸适体,因此本文将重点介绍利用人工智能和生物信息学的最新选择方法,并总结针对刺突蛋白和其他参与SARS-CoV-2进入的新型受体蛋白的核酸适体的最新发现,以及使用单细胞转录组学来确定新的有希望的SARS-CoV-2靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aptamers as Insights for Targeting SARS-CoV-2
The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) continues to be a major cause of high mortality in the world. Despite many therapeutic approaches having been successfully developed, there is still the need to find novel and more effective therapeutic strategies to face the upcoming variants. Here, we will describe the potential use of aptamers, synthetic single-stranded oligonucleotides, as promising tools to target SARS-CoV-2. Since aptamers have been successfully developed against viruses, this review will focus on the latest selection approach method using artificial intelligence, the state-of-the-art in bioinformatics, and we will also summarize the latest discoveries in terms of aptamers against spike protein and other novel receptor proteins involved in SARS-CoV-2 entry and the use of single-cell transcriptomics to define novel promising targets for SARS-CoV-2.
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