Investigation of biochemical profiles derived from different Fritillaria species in Kurdistan Region using GC-MS

Fritillaria species belongs to Liliaceae family, it has been used as medicinal plants in traditional Chinese medicine for more than 2000 years. These plants are known with significant variations in their chemical profiles. Consequently, the characterization of the profile of the major bioactive constituents in various regions are important for pharmaceutical purposes. Despite the identification of numerous species of Fritillaria in Kurdistan, there is no previous study examining phytochemical components of Fritillaria in this region. This study aims to investigate the distribution of major bioactive compounds in wild bulbs of Fritillaria spp. in Kurdistan. 40 compounds were totally detected using Gas Chromatography-Mass Spectrometry (GC-MS). Among the detected compounds, 15 of them were previously found to have effective biological activities. Results have also shown that amongst the underlying Fritillaria species, variations of the types and quantities of the 15 bioactive compounds were significant. This result is of importance for the classification of different Fritillaria. spp. with distinct geographic distributions and medicinal applications.