从几丁质到壳聚糖——一种潜在的天然抗菌剂

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2021-09-30 DOI:10.15259/pcacd.26.003

Zofia Nuc, A. Dobrzycka-Krahel

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引用次数: 3

摘要

甲壳素是一种天然存在的聚合物。与壳聚糖等衍生物一起，它具有广泛的应用可能性，并且许多特性尚未开发。壳聚糖具有许多理想的抗菌聚合物所需的特性。它显示出对抗多重耐药性细菌和真菌菌株的活性，这些菌株对现代医学构成了挑战。壳聚糖还显示出对某些病毒的活性，如严重急性呼吸系统综合征冠状病毒2型。它可能被用作药物或疫苗递送系统，可生物降解、生物利用，并被认为是安全的医疗用途。继续探索壳聚糖的潜力以及研究其来源是很重要的。事实上，这种聚合物的许多来源仍然没有或描述得很差。在本文中，我们汇编了壳聚糖抗菌性能的最新知识，列出了甲壳素的替代来源，以突出这两种聚合物的潜力，并鼓励进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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FROM CHITIN TO CHITOSAN – A POTENTIAL NATURAL ANTIMICROBIAL AGENT

Chitin is a naturally occurring polymer. Together with its derivatives such as chitosan, it has a wide spectrum of application possibilities, and many properties not yet exploited. Chitosan possesses many features desirable in an ideal antimicrobial polymer. It shows activity against multidrug-resistant bacterial and fungal strains that pose a challenge to modern medicine. Chitosan also shows activity against certain viruses, such as SARS-CoV-2. It might be used as a drug or a vaccine delivery system, is biodegradable, bioavailable and considered safe for medical use. It is important to continue exploring the potential of chitosan, as well as to investigate its sources. Indeed, many sources of this polymer are still not or have been poorly described. In this paper, we compile the current state of knowledge on the antimicrobial properties of chitosan, list alternative sources of chitin to highlight the potential of these two polymers and encourage further research.

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.