克罗恩病:传染病合并的观点

IF 0.9 Q4 GASTROENTEROLOGY & HEPATOLOGY
G. Monif
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引用次数: 1

摘要

传染病协会(IDI)是一个传染病智库,成立于1973年。克罗恩病(CD)是一种慢性,反复发作的胃肠道疾病,在工业化国家已达到流行病的比例。据说乳糜泻无药可治。自2003年以来,治疗干预的重点是破坏针对未知抗原的促炎Th1反应。2015年,引入了Hruska假设,并由此解释了在缺乏获得性免疫的情况下,新生儿感染鸟分枝杆菌亚种副结核是如何导致免疫系统对该生物体的Th1反应固定的。赫鲁斯卡假说被用来回答所有记录在案的克罗恩病自然史中的流行病学事实,特别是为什么母乳喂养可以防止克罗恩病的未来发展。传染病公司(IDI)表示,如果在克罗恩病的早期阶段得到适当治疗,克罗恩病是可以预防和治愈的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Crohn’s Disease: The infectious Disease Incorporated’s Perspective
Infectious Diseases Incorporated (IDI) is an infectious disease think-tank, established in 1973. Crohn’s disease (CD) is a chronic, recurrent disease of the gastrointestinal tract that has reached epidemic proportions within industrialized nations. CD is said to be without cure. Since 2003, therapeutic interventions have focused on disruption of the pro-inflammatory Th1 response against an unknown antigen. In 2015, the Hruska Postulate was introduced and, in so doing, explained how, in the absence of acquired immunity, newborn infection by Mycobacterium avium subspecies paratuberculosis could cause fixation of the immune system’s Th1 response against the organism. The Hruska Postulate was utilized to answer all the documented epidemiological facts embedded in the natural history of Crohn’s disease and, in particular, why breastfeeding confers protection against the future development of Crohn’s disease. It is Infectious Diseases Incorporated’s (IDI) stated opinion that Crohn’s disease is both preventable and curable if treated appropriately in its early stages.
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来源期刊
CiteScore
1.50
自引率
0.00%
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审稿时长
10 weeks
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