人乳头瘤病毒相关的口咽部和子宫颈鳞状细胞癌的关联

IF 3.2

Papillomavirus Research Pub Date : 2019-12-01 DOI:10.1016/j.pvr.2019.100188

Malak Jamal Gazzaz , Caroline Jeffery , Daniel O'Connell , Jeffery Harris , Hadi Seikaly , Vincent Biron

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引用次数: 5

摘要

人乳头瘤病毒(HPV)感染在口咽鳞状细胞癌(OPSCC)和宫颈癌(CC)中已经得到了很好的证实。然而，这两种HPV相关癌症之间的关系尚不清楚。本研究的目的是调查口咽部和子宫颈HPV相关癌症之间的关系。方法回顾性分析1997-2015年所有确诊为OPSCC的患者。测量p16+/-OPSCC患者CC病史的标准化发病率(SIR)。结果在372名患有OPSCC的女性中，与加拿大阿尔伯塔省的普通人群相比，CC的SIR在所有年龄段都明显更高(p < 0.0001)。结论HPV/p16+ OPSCC女性发生CC的风险明显高于普通人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Association of human papillomavirus related squamous cell carcinomas of the oropharynx and cervix

Background

Human Papillomavirus (HPV) infection is well established in oropharyngeal squamous cell carcinoma (OPSCC) and cervical cancer (CC). However, the association between both HPV related cancers remains unclear. The purpose of this study was to investigate the association between HPV related cancers of the oropharynx and cervix.

Methods

A provincial cancer registry was used to retrospectively identify all patients diagnosed with OPSCC from 1997-2015. The standardized incidence ratio (SIR) of CC history in women with p16+/-OPSCC was measured.

Results

From 372 women with OPSCC included, the SIR of CC was significantly higher across all ages compared to the general population in Alberta, Canada (p < 0.0001).

Conclusions

Women with HPV/p16+ OPSCC have a significantly higher risk of CC compared to the general population.

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来源期刊

Papillomavirus Research VIROLOGY-

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.