流体生物标记物在神经退行性疾病诊断中的应用

Q2 Medicine

Biomarkers in Neuropsychiatry Pub Date : 2023-06-01 DOI:10.1016/j.bionps.2023.100062

Matthew Luebke , Manisha Parulekar , Florian P. Thomas

{"title":"流体生物标记物在神经退行性疾病诊断中的应用","authors":"Matthew Luebke , Manisha Parulekar , Florian P. Thomas","doi":"10.1016/j.bionps.2023.100062","DOIUrl":null,"url":null,"abstract":"<div><p>In this review, we evaluate the role of fluid biomarkers related to neurodegenerative diseases. Such conditions present diagnostic challenges due to phenotypic heterogeneity, longitudinal evolution, overlap between diagnostic entities, and variability in progression. Biomarkers can potentially provide insight into diagnosis, progression, prognostication, and treatment efficacy. This review covers recent advances in fluid biomarkers including beta-amyloid, tau protein, neurofilament light chain, alpha-synuclein and glial fibrillary protein, and briefly touches upon imaging biomarkers. For each biomarker, we discuss the pathophysiological correlates, clinical uses, accuracy, and limitations.</p></div>","PeriodicalId":52767,"journal":{"name":"Biomarkers in Neuropsychiatry","volume":"8 ","pages":"Article 100062"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Fluid biomarkers for the diagnosis of neurodegenerative diseases\",\"authors\":\"Matthew Luebke , Manisha Parulekar , Florian P. Thomas\",\"doi\":\"10.1016/j.bionps.2023.100062\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this review, we evaluate the role of fluid biomarkers related to neurodegenerative diseases. Such conditions present diagnostic challenges due to phenotypic heterogeneity, longitudinal evolution, overlap between diagnostic entities, and variability in progression. Biomarkers can potentially provide insight into diagnosis, progression, prognostication, and treatment efficacy. This review covers recent advances in fluid biomarkers including beta-amyloid, tau protein, neurofilament light chain, alpha-synuclein and glial fibrillary protein, and briefly touches upon imaging biomarkers. For each biomarker, we discuss the pathophysiological correlates, clinical uses, accuracy, and limitations.</p></div>\",\"PeriodicalId\":52767,\"journal\":{\"name\":\"Biomarkers in Neuropsychiatry\",\"volume\":\"8 \",\"pages\":\"Article 100062\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomarkers in Neuropsychiatry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666144623000023\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomarkers in Neuropsychiatry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666144623000023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 1

摘要

在这篇综述中，我们评估了与神经退行性疾病相关的液体生物标志物的作用。由于表型异质性、纵向进化、诊断实体之间的重叠以及进展的可变性，这种情况带来了诊断挑战。生物标志物可以提供对诊断、进展、预后和治疗效果的深入了解。这篇综述涵盖了流体生物标志物的最新进展，包括β淀粉样蛋白、tau蛋白、神经丝轻链、α突触核蛋白和神经胶质原纤维蛋白，并简要介绍了成像生物标志物。对于每种生物标志物，我们讨论了病理生理相关性、临床用途、准确性和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Fluid biomarkers for the diagnosis of neurodegenerative diseases

In this review, we evaluate the role of fluid biomarkers related to neurodegenerative diseases. Such conditions present diagnostic challenges due to phenotypic heterogeneity, longitudinal evolution, overlap between diagnostic entities, and variability in progression. Biomarkers can potentially provide insight into diagnosis, progression, prognostication, and treatment efficacy. This review covers recent advances in fluid biomarkers including beta-amyloid, tau protein, neurofilament light chain, alpha-synuclein and glial fibrillary protein, and briefly touches upon imaging biomarkers. For each biomarker, we discuss the pathophysiological correlates, clinical uses, accuracy, and limitations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Biomarkers in Neuropsychiatry Medicine-Psychiatry and Mental Health

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

7 weeks