该基因与另一种锌指蛋白1 (JAZF1)在印度人2型糖尿病发病中的作用

K. Dev
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引用次数: 0

摘要

2型糖尿病(T2DM)是一种以胰腺β细胞功能障碍和胰岛素抵抗为特征的慢性疾病。本研究旨在了解JAZF1基因的遗传变异与印度人群中2型糖尿病的关系。采用PCR-RFLP方法进行多态性研究。收集生化参数对半结构化问卷进行统计分析,并利用SPSS软件进行与多态性的相关分析。T2DM组与对照组甘油三酯、HbA1c、t -胆固醇、LDL-C、BMI、收缩压、舒张压、PPG、FPG差异有统计学意义,HDL-C、WHR差异无统计学意义。我们的研究结果表明,JAZF1 rs864745变异与印度人群中的T2D显著相关。本研究认为遗传变异和生化因素的关联在T2DM风险和患病率中起着至关重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
On the Efficacy of the Gene, Juxtaposed with Another Zinc Finger Protein 1 (JAZF1) in the Development of Type 2 Diabetes Mellitus among Indians
Type 2 diabetes mellitus (T2DM) is a chronic disorder characterized by pancreatic beta-cell dysfunction and insulin resistance. The present study was designed to understand the association of genetic variations in the JAZF1 gene with T2DM in the Indian population. The polymorphic study was conducted by PCR-RFLP methods. Further, the biochemical parameters were collected for statistical analysis on the semi-structured questionnaire, and correlation with the polymorphism was done by using SPSS software. The significant differences were observed between T2DM cases and controls in triglycerides, HbA1c, T-cholesterol, LDL-C, BMI, systolic and diastolic BP, PPG, FPG, while no significant differences were observed in HDL-C, WHR. Our results suggested that the JAZF1 rs864745 variant is significantly associated with T2D among the Indian population. The present study concludes that the association of genetic variations and biochemical factors play a vital role in T2DM risk and its prevalence.
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来源期刊
Bioscience Biotechnology Research Communications
Bioscience Biotechnology Research Communications BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
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