人血清白蛋白- spions负载PLGA纳米颗粒蛋白递送的研究

生物化学进展(英文) Pub Date : 2018-10-24 DOI:10.4236/ABC.2018.85008

S. Vidawati, S. Barbosa, P. Taboada, Eva M. Villar, A. Topete, V. Mosquera

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引用次数: 9

摘要

聚乳酸-乙醇酸（PLGA）的可生物降解纳米颗粒已被广泛研究用于不同药物的持续和靶向/局部递送。在可生物降解的聚合物纳米颗粒的合成中需要许多参数。我们报道了人血清白蛋白（HSA）-超顺磁性氧化铁纳米粒子（SPIONs）负载PLGA纳米粒子的合成。使用TEM图像、UV-Vis光谱测量、Zeta电位和用于磁化的PPMS对所有纳米颗粒进行表征。本研究描述并研究了HSA SPION负载PLGA纳米颗粒的合成和发展中的有趣现象。结果表明，HSA SPION负载的PLGA纳米颗粒的稳定性具有潜在的应用，如蛋白质递送。

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Study of Human Serum Albumin-SPIONs Loaded PLGA Nanoparticles for Protein Delivery

The Biodegradable nanoparticles from poly(lactic-co-glycolic acid) (PLGA) have been extensively investigated for sustained and targeted/localized delivery of different agents. Many parameters are required in the synthesis of a biodegradable polymeric nanoparticle. We report the synthesis of human serum albumin (HSA)-superparamagnetic iron oxide nanoparticles (SPIONs) loaded PLGA nanoparticles. All nanoparticles were characterized using a TEM image, UV-Vis spectroscopy measurements, Zeta Potential, and PPMS for magnetizations. This study described and investigated the interesting phenomenon in the synthesis development of HSA-SPIONs loaded PLGA nanoparticles. The result showed that the stability of HSA-SPIONs loaded PLGA nanoparticles for potential applications such as in protein delivery.

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来源期刊

生物化学进展(英文)

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251