聚甲基染料在光动力治疗中的结构及光敏性研究进展

IF 0.7 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Theoretical and Experimental Chemistry Pub Date : 2023-04-04 DOI:10.1007/s11237-023-09754-9

A. A. Ishchenko, A. T. Syniugina

{"title":"聚甲基染料在光动力治疗中的结构及光敏性研究进展","authors":"A. A. Ishchenko, A. T. Syniugina","doi":"10.1007/s11237-023-09754-9","DOIUrl":null,"url":null,"abstract":"<div><div><p>Different approaches to the development of promising photosensitizers based on polymethine dyes (PD) for photodynamic therapy are systematized, summarized, and analyzed. PD of the near-IR spectral range has drawn special attention. The influence of a heavy atom (chalcogens, halogens, and noble metals), the chromophore interaction, electron transfer, and free radicals on the singlet oxygen generation by PD is discussed. The PD photodynamic activity mechanisms under hypoxia conditions are considered. The PD structural modifications that ensure their targeted delivery to cancer cells are analyzed.</p></div></div>","PeriodicalId":796,"journal":{"name":"Theoretical and Experimental Chemistry","volume":"58 6","pages":"373 - 401"},"PeriodicalIF":0.7000,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Structure and Photosensitaizer Ability of Polymethine Dyes in Photodynamic Therapy: A Review\",\"authors\":\"A. A. Ishchenko, A. T. Syniugina\",\"doi\":\"10.1007/s11237-023-09754-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div><p>Different approaches to the development of promising photosensitizers based on polymethine dyes (PD) for photodynamic therapy are systematized, summarized, and analyzed. PD of the near-IR spectral range has drawn special attention. The influence of a heavy atom (chalcogens, halogens, and noble metals), the chromophore interaction, electron transfer, and free radicals on the singlet oxygen generation by PD is discussed. The PD photodynamic activity mechanisms under hypoxia conditions are considered. The PD structural modifications that ensure their targeted delivery to cancer cells are analyzed.</p></div></div>\",\"PeriodicalId\":796,\"journal\":{\"name\":\"Theoretical and Experimental Chemistry\",\"volume\":\"58 6\",\"pages\":\"373 - 401\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Theoretical and Experimental Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11237-023-09754-9\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Theoretical and Experimental Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11237-023-09754-9","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 7

摘要

本文系统、总结和分析了基于聚甲基染料(PD)的光敏剂在光动力治疗中的应用前景。近红外光谱范围的PD引起了人们的特别关注。讨论了重原子(硫、卤素和贵金属)、发色团相互作用、电子转移和自由基对PD生成单线态氧的影响。探讨了PD在缺氧条件下的光动力学活性机制。PD结构的修改，确保其靶向递送到癌细胞进行了分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Structure and Photosensitaizer Ability of Polymethine Dyes in Photodynamic Therapy: A Review

查看原文本刊更多论文

Structure and Photosensitaizer Ability of Polymethine Dyes in Photodynamic Therapy: A Review

Different approaches to the development of promising photosensitizers based on polymethine dyes (PD) for photodynamic therapy are systematized, summarized, and analyzed. PD of the near-IR spectral range has drawn special attention. The influence of a heavy atom (chalcogens, halogens, and noble metals), the chromophore interaction, electron transfer, and free radicals on the singlet oxygen generation by PD is discussed. The PD photodynamic activity mechanisms under hypoxia conditions are considered. The PD structural modifications that ensure their targeted delivery to cancer cells are analyzed.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Theoretical and Experimental Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.60

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Theoretical and Experimental Chemistry is a journal for the rapid publication of research communications and reviews on modern problems of physical chemistry such as: a) physicochemical bases, principles, and methods for creation of novel processes, compounds, and materials; b) physicochemical principles of chemical process control, influence of external physical forces on chemical reactions; c) physical nanochemistry, nanostructures and nanomaterials, functional nanomaterials, size-dependent properties of materials.