乳液界面反应法制备壳聚糖负载萘普生纳米颗粒及其性能评价

Q2 Pharmacology, Toxicology and Pharmaceutics

Drug Delivery Letters Pub Date : 2019-05-15 DOI:10.2174/2210303109666190211150117

A. Sailaja, J. Banu

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引用次数: 0

摘要

采用乳化液界面反应法制备了萘普生负载壳聚糖颗粒，并对其进行了表征。采用壳聚糖作为聚合物进行乳液界面反应。在该方法中，通过改变药物与聚合物的浓度，制备了8种制剂。采用乳液界面反应法制备的8个配方中，EI8为最佳配方。所得样品中药物含量为94.4%，包封率为87.5%，载药量为75%。平均粒径为324.6nm, Zeta电位值为-42.4mv。体外释药数据显示，97.2%的释药率持续时间长达12小时。结果表明，EI8平均粒径小，包封效率好，稳定性好，给药量最高，为最佳配方。

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Preparation and Evaluation of Chitosan Loaded Naproxen Nanoparticles by Emulsion Interfacial Reaction Method

The aim of this investigation was to develop and characterize naproxen loaded chitosan nanoparticles by emulsion interfacial reaction method. For emulsion interfacial reaction method chitosan was used as a polymer. In this method, eight formulations were prepared by varying drug to polymer concentration. Out of eight formulations prepared using emulsion interfacial reaction method EI8 formulation was found to be the best formulation. The drug content was observed as 94.4%, entrapment efficiency and loading capacity were found to be 87.5% and 75%, respectively. The mean particle diameter was measured as 324.6nm and the Zeta potential value was found to be -42.4mv. In vitro drug release data showed 97.2% of drug release rate sustained up to 12hrs. The results clearly reveal that EI8 formulation having the highest amount of drug was considered as the best formulation because of its small mean particle diameter, good entrapment efficiency, and stability.

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来源期刊

Drug Delivery Letters Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.70

自引率

0.00%

发文量