使用MALDI-TOF-MS表征季节性变应性鼻炎的血清n -糖苷改变:一项初步研究

IF 1.2 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Carbohydrate Chemistry Pub Date : 2021-01-01 DOI:10.1080/07328303.2021.2009502

Mehmet Emrah Yaman , Izzet Avci , Nihal Efe Atila , Alptug Atila , Haci Mehmet Kayili , Bekir Salih

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引用次数: 1

摘要

季节性变应性鼻炎(SAR)是一种炎症过程。在这项初步研究中，基于基质辅助激光解吸电离-质谱(MALDI-MS)的分析在一个小数据集(n = 10, SAR患者和对照组)中研究了SAR对血清n-糖的影响。检测到两种n-聚糖组成(H6N5E2L1和H6N5E1L2)在SAR患者中下调。此外，半乳糖化和涎化(A3GS和A3GL)和非聚焦化(A3F0GE、A3F0GL、A3F0GS)的五种三触角n-聚糖性状均降低。此外，与对照组相比，SAR患者的三个高触角和集中的n -聚糖特征(A3F, A3EF和A4F)增加。

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Characterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot study

Seasonal allergic rhinitis (SAR) is an inflammatory process. In this pilot study, matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS)-based analyses were conducted to investigate the effects of SAR on serum N-glycome in a small dataset (n = 10 for both SAR patients and controls). It was detected that two N-glycan compositions (H6N5E2L1 and H6N5E1L2) were down-regulated in SAR patients. Additionally, five tri-antennary N-glycan traits, including both galactosylated and sialylated (A3GS and A3GL) and non-fucosylated (A3F0GE, A3F0GL, A3F0GS) ones, were decreased. Furthermore, three high-antennary and fucosylated N-glycan traits (A3F, A3EF and A4F) were increased in SAR patients compared to controls.

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来源期刊

Journal of Carbohydrate Chemistry 化学-生化与分子生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.