消二肺咳喘颗粒治疗小儿支气管肺炎的疗效及对血清APC、IL-1R的影响

中国基层医药 Pub Date : 2020-03-01 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.05.006

Rong-bo Jia

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引用次数: 0

摘要

目的观察小儿咳喘颗粒治疗小儿支气管肺炎的疗效及其对血清活化蛋白（APC）和白细胞介素1受体（IL-1R）的影响。方法选择2016年6月至2018年6月入住丽水市妇幼保健院的116例儿童支气管肺炎患儿作为观察对象。根据随机数表法，将患者分为观察组和对照组，每组58例。两组均给予常规治疗。在此基础上，观察组给予消尔非热咳喘颗粒治疗，观察治疗前后疗效、临床症状消失时间、APC和IL-1R水平的变化。结果治疗后观察组总有效率为96.55%，高于对照组81.03%，差异有统计学意义（χ2=7.017，P=0.008），观察组X线炎症消失时间和咳嗽消失时间均短于对照组，差异有统计学意义（t=9.134、13.157、3.407、8.532，均P<0.05），观察组ACP水平高于对照组（t=5.209，P<0.05）；两组患儿血清IL-1R水平均下降（均P<0.05），观察组IL-1R水平低于对照组（t=11.835，P<0.05），其机制可能与降低血清IL-1R水平和提高APC水平有关。关键词：消尔非热咳喘颗粒；支气管肺炎；中西医结合治疗；活化蛋白；IL-1R；功效；改善症状

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Effect of Xiaoerfeire Kechuan Granule in the treatment of children with bronchopneumonia and its effect on serum APC and IL-1R

Objective To observe the effect of Xiaoerfeire Kechuan Granule in the treatment of bronchopneumonia in children and its effect on serum activating protein(APC) and interleukin-1 receptor(IL-1R). Methods From June 2016 to June 2018, 116 children with pediatric bronchial pneumonia admitted to the Maternal and Child Health Hospital of Lishui were selected as observation subjects.According to the random number table method, the patients were divided into observation group and control group, with 58 cases in each group.Both two groups were given conventional therapy.On the basis of this treatment, the observation group was treated with Xiaoerfeire Kechuan Granule.The therapeutic effects, the disappearance time of clinical symptoms, and the changes of APC and IL-1R levels before and after treatment were observed. Results After treatment, the total effective rate of the observation group was 96.55%, which was higher than that of the control group(81.03%), the difference was statistically significant(χ2=7.017, P=0.008). The defervescence time, lung voice disappeared time, disappearance time of X-ray inflammation and disappearance time of cough in the observation group were shorter than those in the control group, and the differences were statistically significant(t=9.134, 13.157, 3.407, 8.532, all P 0.05). After treatment, the serum ACP levels increased in both two groups(all P<0.05), and the ACP level of the observation group was higher than that of the control group(t=5.209, P<0.05); the serum IL-1R level of the two groups were decreased(all P<0.05), and the IL-1R level of the observation group was lower than that of the control group (t=11.835, P<0.05). Conclusion Xiaoerfeire Kechuan Granule is effective in the treatment of children with bronchopneumonia, which can improve the clinical symptoms of children rapidly, its mechanism may be related to lowering serum IL-1R level and increasing APC level. Key words: Xiaoerfeire Kechuan Granule; Bronchial pneumonia; Integrated Chinese and western medicine therapy; activating protein; IL-1R; Efficacy; Improve symptoms

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来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.