闪光放射治疗

中华放射肿瘤学杂志 Pub Date : 2019-11-15 DOI:10.3760/CMA.J.ISSN.1004-4221.2019.11.014

Wei Zhao, Yuan Tian, Hao Peng

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引用次数: 3

摘要

闪光放射治疗（Flash RT）是一种使用超高剂量率和超快辐射诱导的正常组织保留方案的治疗方式。与常规剂量率放疗相比，Flash RT有可能在实现显著的正常组织保护的同时，为肿瘤提供等效性。由于这种独特的特性，Flash RT越来越受到放射治疗界的关注。来自学术界和工业界的许多团体正在广泛研究治疗比例和潜在的生物学机制。在这里，我们回顾了先前关于Flash RT的知识，并总结了使用不同实验方案的体外和动物研究从各个小组报告的结果。我们还讨论了可能的生物学机制和实施Flash RT的挑战，以及其临床应用的可能选择。关键词：闪光放射治疗；剂量率；剂量测定；缺氧；超快辐照

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Flash radiotherapy

Flash radiotherapy (Flash-RT) is a treatment modality that uses the normal tissue sparing regimen induced by ultra-high dose rate and ultra-fast irradiation. Compared to conventional dose rate radiotherapy, Flash-RT has the potential to provide the isoefficacy for tumors while achieving the remarkable normal tissue protection. Due to this unique feature, Flash-RT is attracting more and more attention from the radiotherapy community. An abundance of groups from both academia and industry are extensively studying the therapeutic ratio and underlying biological mechanisms. Here, we review the prior knowledge about Flash-RT and summarize the results that have been reported from various groups using both in vitro and animal studies with different experimental protocols. We also discuss possible biological mechanisms and the challenging of implementing Flash-RT, as well as its possible options for clinical applications. Key words: Flash radiotherapy; Dose rate; Dosimetry; Hypoxia; Ultra-fast irradiation

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来源期刊

中华放射肿瘤学杂志

自引率

0.00%

发文量

6375

期刊介绍： The Chinese Journal of Radiation Oncology is a national academic journal sponsored by the Chinese Medical Association. It was founded in 1992 and the title was written by Chen Minzhang, the former Minister of Health. Its predecessor was the Chinese Journal of Radiation Oncology, which was founded in 1987. The journal is an authoritative journal in the field of radiation oncology in my country. It focuses on clinical tumor radiotherapy, tumor radiation physics, tumor radiation biology, and thermal therapy. Its main readers are middle and senior clinical doctors and scientific researchers. It is now a monthly journal with a large 16-page format and 80 pages of text. For many years, it has adhered to the principle of combining theory with practice and combining improvement with popularization. It now has columns such as monographs, head and neck tumors (monographs), chest tumors (monographs), abdominal tumors (monographs), physics, technology, biology (monographs), reviews, and investigations and research.