高效抗菌剂铬-2- 1、吡喃[3,4-c]铬及吡喃[3,4-c]铬衍生物的合成

IF 0.7 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Croatica Chemica Acta Pub Date : 2018-01-02 DOI:10.5562/CCA3266

Sawsan A. Fouad, S. Hessein, S. Abbas, A. Farrag, Y. Ammar

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引用次数: 14

摘要

在尝试开发新的抗菌剂;合成了含重氮基团的新系列铬-2- 1、吡喃[3,4-c]铬和吡喃[3,4-c]铬衍生物。以5-(芳基重偶氮)水杨醛为原料，用不同类型的活性亚甲基衍生物处理，合成了2- 1型铬- 1衍生物。用活性亚甲基衍生物对2- 1型铬- 1衍生物进行处理，合成了吡喃[3,4-c]铬和吡喃[3,4-c]铬衍生物。对合成的化合物进行了抗菌活性评价;其中，大多数化合物对所测试的细菌和真菌菌株显示出有效的抗菌和抗真菌活性。

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Synthesis of Chromen-2-one, Pyrano[3,4-c]chromene and Pyridino[3,4-c]chromene Derivatives as Potent Antimicrobial Agents

In an attempt for development of new antimicrobial agents; new series of chromen-2-one, pyrano[3,4-c]chromene and pyridino[3,4c]chromene derivatives bearing a diazo moiety were synthesized. Chromen-2-one derivatives were synthesized via treatment of 5-(aryldiazo) salicylaldehyde with different type of active methylene derivatives. Pyrano[3,4-c]chromene and pyridino[3,4-c]chromene derivatives were synthesized via treatment of chromen-2-one derivatives with another active methylene derivatives. The synthesized compounds were evaluated for their expected antimicrobial activity; where, the majority of these compounds showed potent antibacterial and antifungal activities against the tested strains of bacteria and fungi.

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来源期刊

Croatica Chemica Acta 化学-化学综合

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

18 months

期刊介绍： Croatica Chemica Acta (Croat. Chem. Acta, CCA), is an international journal of the Croatian Chemical Society publishing scientific articles of general interest to chemistry.