中国老年妇女外周血中性粒细胞比例与骨质疏松症的关系

中国基层医药 Pub Date : 2020-03-15 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.06.015

Yan Qin, Li-xing Xu, Dong Peng, Yi Wang, Chunfen Li, Yan-Li Zhou, Tian Chen, Peng Zhang, Chengjing Tang, J. Xia, Yan Li

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引用次数: 0

摘要

目的探讨中国老年妇女外周血中性粒细胞淋巴细胞比率（NLR）与原发性骨质疏松症（POP）的关系。方法2015年12月至2019年4月，重庆三峡中心医院788名老年妇女参与本研究。根据骨密度将他们分为三组：242例骨质减少症、206例正常骨密度症和340例骨质疏松症。记录他们的身高、体重、左股骨颈骨骼状况和血液检查结果，并计算BMI、NLR和OSTA值。采用SPSS统计软件分析三组患者的各项参数差异。采用Logistic回归分析得到骨质疏松症的显著独立相关因素。Pearson相关检验证实了NLR和OSTA与左股骨颈T评分的关系。ROC曲线用于确定NLR和OSTA在骨质疏松症诊断中的价值。结果三组患者的年龄（中位数：66、68、70，χ2=71.596，P<0.001）、BMI（中位数：23.46、24.04、25.415，χ2=64.936，P=0.001）和NLR（中位数：1.97、2.435、2.84，χ2=106.218，P<0.001，均为显著性差异（均P<0.01）。NLR、OSTA与左股骨颈T积分呈正相关。在骨质疏松症的诊断中，NLR的临界值、最大Youden指数、敏感性和特异性分别为2.395、0.299、70.3%、59.6%和-1.315、0.174、73.6%、43.5%。结论NLR在中国老年妇女POP筛查中具有中等敏感性和特异性，值得进一步研究。关键词：骨质疏松症；颗粒细胞；淋巴细胞；OSTA；骨密度；敏感性；特异性；ROC曲线；老化

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Relationship between peripheral blood neutrophil lymphocyte ratio and osteoporosis in Chinese elderly women

Objective To explore the association of peripheral blood neutrophil lymphocyte ratio(NLR) with primary osteoporosis (POP) in Chinese elderly women. Methods From December 2015 to April 2019, a total of 788 elderly women in Chongqing Three Gorges Central Hospital were included in this study.They were divided into three groups according to bone mineral density: 242 cases of osteopenia, 206 cases of normal bone mineral density and 340 cases of osteoporosis.Their height, weight, statuses of bone of left femoral neck and results of blood tests were recorded, and the values of BMI, NLR and OSTA were calculated.The SPSS statistics software was used to analyze the differences of parameters among the three groups.Logistic regression analysis was used to get significant independent related factors for osteoporosis.The relationship of NLR and OSTA with T-score of left femoral neck was confirmed by Pearson correlation test.ROC curves were used to define the values of NLR and OSTA in diagnosis of osteoporosis. Results There were statistically significant differences in age(median values: 66, 68 and 70, χ2=71.596, P<0.001), BMI(median values: 23.46, 24.04 and 25.415, χ2=64.936, P<0.001) and NLR(median values: 1.97, 2.435 and 2.84, χ2=106.218, P<0.001) among the three groups(all P<0.01). Logistic regression analysis demonstrated that age, BMI and NLR were all independent significant related factors.There was correlation of NLR, OSTA with T-score of left femoral neck.In diagnosis of osteoporosis, the cut-off value, maximum Youden index, sensitivity and specificity were 2.395, 0.299, 70.3%, 59.6% for NLR, and -1.315, 0.174, 73.6%, 43.5% for OSTA. Conclusion NLR has intermediate sensitivity and specificity in screening POP in Chinese elderly women, and deserves future researches. Key words: Osteoporosis; Granulocytes; Lymphocytes; OSTA; Bone mineral density; Sensitivity; Specificity; ROC curve; Aged

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来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.