球体作为药物测试的三维细胞模型

European Pharmaceutical Journal Pub Date : 2023-08-24 DOI:10.2478/afpuc-2023-0008

E. Nováková, V. Mikušová, M. Šupolíková

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引用次数: 0

摘要

细胞系是科学研究、临床和医药应用的重要工具。细胞是从动物组织中分离出来的，可以在培养中扩增，以研究细胞生物学和疾病。分离的细胞可用于生产抗体、蛋白质和疫苗。永生化细胞系可以在体外生长，通常用作复杂生物学的模型。科学研究、临床和制药应用中最常用的细胞培养类型是二维(2D)模型，但最近，三维(3D)培养方法的普及程度越来越高。

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Spheroids as 3D Cell Models for Testing of Drugs

Abstract Cell lines are an important tool for scientific research and clinical and pharmaceutical applications. Cells are isolated from animal tissues and can be expanded in culture to study cell biology and disease. The isolated cells can be used to produce antibodies, proteins, and vaccines. Immortalized cell lines can grow in vitro and are commonly used as models for complex biology. The most frequently used type of cell culture for scientific research and clinical and pharmaceutical applications is the two-dimensional (2D) model, but recently, the popularity of the three-dimensional (3D) cultivation method is growing.

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.