糖皮质激素超昼夜节律

Current Opinion in Endocrine and Metabolic Research Pub Date : 2022-08-01 DOI:10.1016/j.coemr.2022.100362

Benjamin P. Flynn

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引用次数: 1

摘要

超微糖皮质激素节律在哺乳动物物种中高度保守，并在周期性动态信号网络中稳定振荡。尽管如此，在时间生物学研究中，超昼夜信号的作用及其失调对认知加工和代谢稳态的影响经常被忽视。本文将讨论超肽特异性信号和转录机制，以及超肽失调对认知和代谢功能的影响。强调可能对未来患者护理和治疗产生重大影响的新兴治疗方法。

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Glucocorticoid ultradian rhythms

Ultradian glucocorticoid rhythms are highly conserved across mammalian species and robustly oscillate within a cyclical dynamic signalling network. Despite this, the role of ultradian signalling and the effects of its dysregulation for cognitive processing and metabolic homeostasis is often overlooked within chrono-biological research. This review will discuss ultradian specific signalling and transcriptional mechanisms and the proposed models and repercussion of ultradian dysregulation for cognitive and metabolic function. Highlighting emerging therapeutic treatment that may have significant impacts for future patient care and treatment.

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来源期刊

Current Opinion in Endocrine and Metabolic Research Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

4.10

自引率

0.00%

发文量