1,25（OH）2D3、维甲酸和白细胞介素-4反式激活小鼠骨髓巨噬细胞的β3整合素基因调节αvβ3整合素

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-08-10 DOI:10.1267/ahc.19015

S. Kitazawa, Ryuma Haraguchi, Y. Kohara, R. Kitazawa

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引用次数: 1

摘要

白细胞介素(IL)- 4,1,25 (OH)2D3和维甲酸可增加小鼠破骨细胞前体表面功能性整合素αvβ3的表达。所有三种激动剂都刺激β3基因的转录，导致该蛋白mRNA的稳态水平增加。相比之下，αv的mRNA水平保持不变。在每种情况下，整合素表面表达的增加导致细胞迁移到αvβ3底物上的增加。由于除了血小板中β3亚基与αIIb为二聚体外，β3亚基仅与αv亚基单偶结合，而αv亚基与多种亚基混杂结合，我们目前的数据支持β3亚基控制表面表达的功能性整合素复合物的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Modulation of αvβ3 Integrin via Transactivation of β3 Integrin Gene on Murine Bone Marrow Macrophages by 1,25(OH)2D3, Retinoic Acid and Interleukin-4

The interleukin (IL)-4, 1,25(OH)2D3 and retinoic acid, increase surface expression of functional integrin αvβ3 on murine osteoclast precursors. All three agonists stimulate transcription of the β3 gene, leading to increased steady-state levels of mRNA this protein. By contrast, mRNA levels of αv remain unchanged. In each instance, the increase in the surface expression of the integrin results in increased migration of the cells onto an αvβ3 substrate. Because β3 subunit, except platelet where β3 subunit conform a dimer with αIIb, associates solely with αv subunit monogamously, while promiscuous αv subunit combines with various subunit, our present data support the idea that the β3 subunit governs the surface-expressed functional integrin complex.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.