加速损伤条件下,分裂和自噬对线粒体功能的影响:一种数学建模方法

IF 1.3 Q3 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS
Ángel J. Zamora-Ramírez, M. Santillán
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引用次数: 0

摘要

越来越多的证据表明,线粒体动力学在线粒体功能质量控制中发挥作用。最近的研究发现,体育活动有助于维持健康的线粒体种群,甚至可能通过改变线粒体动力学过程(如线粒体发生、分裂和线粒体自噬)来抵消肥胖引起的线粒体损伤。然而,其潜在机制及其如何影响线粒体动力学的各种过程尚未完全阐明。这项研究试图通过利用数学建模来研究线粒体动力学过程的改变如何有助于在加速损伤的条件下保持健康的线粒体种群,从而填补这一空白。我们通过分析模型稳态行为发现,裂变和线粒体自噬是健康线粒体群体的严格要求,增加线粒体损伤率对功能性线粒体群体有负面影响,并且可以通过增加裂变和/或线粒体自噬率在一定程度上减轻这种损伤。这些发现最后在体育活动对肥胖个体线粒体群体健康的益处的背景下进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of fission and mitophagy on mitochondrial functionality under accelerated damage conditions: A mathematical modeling approach
There is growing evidence that mitochondrial dynamics play a role in mitochondrial function quality control. Recent studies have discovered that physical activity can aid in maintaining a healthy mitochondrial population and may even counteract the mitochondrial damage caused by obesity by modifying mitochondrial dynamics processes like mitogenesis, fission, and mitophagy. However, the underlying mechanisms and how they influence the various processes of mitochondrial dynamics have not been completely clarified. This study seeks to make an initial effort to fill this gap by utilizing mathematical modeling to investigate how modifications to the processes involved in mitochondrial dynamics can aid in preserving a healthy mitochondrial population under conditions of accelerated damage. We found by analyzing the model stationary behavior that fission and mitophagy are strictly required for a healthy mitochondrial population, that increasing the rate of mitochondrial damage has a negative impact on the population of functional mitochondria, and that such damage can be mitigated to some extent by increasing fission and/or mitophagy rates. These findings are finally discussed in the context of the benefits of physical activity for mitochondrial population health in obese individuals.
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来源期刊
Frontiers in Applied Mathematics and Statistics
Frontiers in Applied Mathematics and Statistics Mathematics-Statistics and Probability
CiteScore
1.90
自引率
7.10%
发文量
117
审稿时长
14 weeks
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