Nocardiopyrone C:一种新型埃及诺卡芽孢杆菌ZSN1的抗菌Pyran-2-one衍生物

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2023-07-11 DOI:10.25135/rnp.405.2304.2763

Jiang Yongjun, Zi-jun Chen, Yuhong Tian, Mingzhu Ma

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引用次数: 0

摘要

从海洋来源的埃及诺卡opsis aegyptia ZSN1中鉴定出新的吡喃-2- 1衍生物Nocardiopyrone C(1)和三个已知化合物Nocardiopyrone B(2)、1-羟基-4-甲氧基-2-萘酸(3)和2-(氨基羰基)-苯氨基甲酸酯(4)。新化合物(1)的化学结构为(7r)-5-(甲氧基甲基)-3-甲基-6-(戊烷-2-基)-2 H -吡喃-2- 1。4个化合物均具有抗菌活性，其中新化合物1对大肠杆菌、金黄色葡萄球菌和白色念珠菌的MIC值相同，均为50.0µM。

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Nocardiopyrone C, a New Antimicrobial Pyran-2-one Derivative from a Marine-derived Actinomycete Strain Nocardiopsis aegyptia ZSN1

: A new pyran-2-one derivative, Nocardiopyrone C ( 1 ), and three known compounds, Nocardiopyrone B ( 2 ), 1-hydroxy-4-methoxy-2-naphthoic acid ( 3 ), and 2-(aminocarbonyl)-phenylcarbamate ( 4 ) were identified from the marine-derived Nocardiopsis aegyptia ZSN1. The chemical structure of the novel compound ( 1 ) was ascertained as (7 R )-5-(methoxymethyl)-3-methyl-6-(pentan-2-yl)-2 H -pyran-2-one using HRESIMS data, spectroscopic data, and ECD calculations. All four isolated compounds displayed antimicrobial activity, with the new compound 1 having the same MIC value of 50.0 µ M against E. coli , S. aureus , and C. albicans .

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.