{"title":"电解质性质的原料药对溶液中果胶大分子构象和超分子状态的影响","authors":"M. A. Afanas’eva, A. S. Shurshina, E. I. Kulish","doi":"10.1134/S1560090423700653","DOIUrl":null,"url":null,"abstract":"<p>Effect of a number of low-molecular-weight drug substances on the viscous and rheological behavior of pectin solutions in dilute and semidilute solutions regimes is studied. It is shown that the introduction of a drug substance, which is a low molecular weight electrolyte, into a dilute pectin solution leads to a change in the intrinsic viscosity of the polymer and the degree of aggregation of its macromolecules. Upon introduction of the drug substance into a semidilute pectin solution the rheological behavior of the solution changes. Presence of a drug substance of the nonelectrolyte nature in pectin solution has almost no effect on the conformational and supramolecular state of pectin and, accordingly, the viscosity characteristics of solution. It is demonstrated that the electrolyte drug substances, especially polyvalent cations, affect some practically important properties of liquid and soft dosage forms produced from pectin solutions, specifically the yield stress and the rate of drug substance release. The results obtained are explained by the polyelectrolyte nature of pectin.</p>","PeriodicalId":739,"journal":{"name":"Polymer Science, Series B","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Drug Substances of the Electrolyte Nature on the Conformational and Supramolecular State of Pectin Macromolecules in Solution\",\"authors\":\"M. A. Afanas’eva, A. S. Shurshina, E. I. Kulish\",\"doi\":\"10.1134/S1560090423700653\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Effect of a number of low-molecular-weight drug substances on the viscous and rheological behavior of pectin solutions in dilute and semidilute solutions regimes is studied. It is shown that the introduction of a drug substance, which is a low molecular weight electrolyte, into a dilute pectin solution leads to a change in the intrinsic viscosity of the polymer and the degree of aggregation of its macromolecules. Upon introduction of the drug substance into a semidilute pectin solution the rheological behavior of the solution changes. Presence of a drug substance of the nonelectrolyte nature in pectin solution has almost no effect on the conformational and supramolecular state of pectin and, accordingly, the viscosity characteristics of solution. It is demonstrated that the electrolyte drug substances, especially polyvalent cations, affect some practically important properties of liquid and soft dosage forms produced from pectin solutions, specifically the yield stress and the rate of drug substance release. The results obtained are explained by the polyelectrolyte nature of pectin.</p>\",\"PeriodicalId\":739,\"journal\":{\"name\":\"Polymer Science, Series B\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polymer Science, Series B\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1560090423700653\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Science, Series B","FirstCategoryId":"1","ListUrlMain":"https://link.springer.com/article/10.1134/S1560090423700653","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Effect of Drug Substances of the Electrolyte Nature on the Conformational and Supramolecular State of Pectin Macromolecules in Solution
Effect of a number of low-molecular-weight drug substances on the viscous and rheological behavior of pectin solutions in dilute and semidilute solutions regimes is studied. It is shown that the introduction of a drug substance, which is a low molecular weight electrolyte, into a dilute pectin solution leads to a change in the intrinsic viscosity of the polymer and the degree of aggregation of its macromolecules. Upon introduction of the drug substance into a semidilute pectin solution the rheological behavior of the solution changes. Presence of a drug substance of the nonelectrolyte nature in pectin solution has almost no effect on the conformational and supramolecular state of pectin and, accordingly, the viscosity characteristics of solution. It is demonstrated that the electrolyte drug substances, especially polyvalent cations, affect some practically important properties of liquid and soft dosage forms produced from pectin solutions, specifically the yield stress and the rate of drug substance release. The results obtained are explained by the polyelectrolyte nature of pectin.
期刊介绍:
Polymer Science, Series B is a journal published in collaboration with the Russian Academy of Sciences. Series B experimental and theoretical papers and reviews dealing with the synthesis, kinetics, catalysis, and chemical transformations of macromolecules, supramolecular structures, and polymer matrix-based composites (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed