电解质性质的原料药对溶液中果胶大分子构象和超分子状态的影响

IF 1 4区 化学 Q4 POLYMER SCIENCE
M. A. Afanas’eva, A. S. Shurshina, E. I. Kulish
{"title":"电解质性质的原料药对溶液中果胶大分子构象和超分子状态的影响","authors":"M. A. Afanas’eva,&nbsp;A. S. Shurshina,&nbsp;E. I. Kulish","doi":"10.1134/S1560090423700653","DOIUrl":null,"url":null,"abstract":"<p>Effect of a number of low-molecular-weight drug substances on the viscous and rheological behavior of pectin solutions in dilute and semidilute solutions regimes is studied. It is shown that the introduction of a drug substance, which is a low molecular weight electrolyte, into a dilute pectin solution leads to a change in the intrinsic viscosity of the polymer and the degree of aggregation of its macromolecules. Upon introduction of the drug substance into a semidilute pectin solution the rheological behavior of the solution changes. Presence of a drug substance of the nonelectrolyte nature in pectin solution has almost no effect on the conformational and supramolecular state of pectin and, accordingly, the viscosity characteristics of solution. It is demonstrated that the electrolyte drug substances, especially polyvalent cations, affect some practically important properties of liquid and soft dosage forms produced from pectin solutions, specifically the yield stress and the rate of drug substance release. The results obtained are explained by the polyelectrolyte nature of pectin.</p>","PeriodicalId":739,"journal":{"name":"Polymer Science, Series B","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Drug Substances of the Electrolyte Nature on the Conformational and Supramolecular State of Pectin Macromolecules in Solution\",\"authors\":\"M. A. Afanas’eva,&nbsp;A. S. Shurshina,&nbsp;E. I. Kulish\",\"doi\":\"10.1134/S1560090423700653\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Effect of a number of low-molecular-weight drug substances on the viscous and rheological behavior of pectin solutions in dilute and semidilute solutions regimes is studied. It is shown that the introduction of a drug substance, which is a low molecular weight electrolyte, into a dilute pectin solution leads to a change in the intrinsic viscosity of the polymer and the degree of aggregation of its macromolecules. Upon introduction of the drug substance into a semidilute pectin solution the rheological behavior of the solution changes. Presence of a drug substance of the nonelectrolyte nature in pectin solution has almost no effect on the conformational and supramolecular state of pectin and, accordingly, the viscosity characteristics of solution. It is demonstrated that the electrolyte drug substances, especially polyvalent cations, affect some practically important properties of liquid and soft dosage forms produced from pectin solutions, specifically the yield stress and the rate of drug substance release. The results obtained are explained by the polyelectrolyte nature of pectin.</p>\",\"PeriodicalId\":739,\"journal\":{\"name\":\"Polymer Science, Series B\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polymer Science, Series B\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1560090423700653\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Science, Series B","FirstCategoryId":"1","ListUrlMain":"https://link.springer.com/article/10.1134/S1560090423700653","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0

摘要

研究了一些低分子量的原料药对果胶溶液在稀、半稀溶液中的粘性和流变性能的影响。结果表明,在稀释的果胶溶液中加入一种低分子量电解质,会导致聚合物的特性粘度和大分子的聚集程度发生变化。在将原料药引入半稀果胶溶液后,溶液的流变行为发生了变化。果胶溶液中存在非电解质性质的原料药,对果胶的构象和超分子状态几乎没有影响,因此对溶液的粘度特性也没有影响。研究表明,电解质原料药,特别是多价阳离子,会影响果胶溶液制备的液体和软剂型的一些实际重要性质,特别是屈服应力和原料药的释放速度。所得结果可以用果胶的聚电解质性质来解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of Drug Substances of the Electrolyte Nature on the Conformational and Supramolecular State of Pectin Macromolecules in Solution

Effect of Drug Substances of the Electrolyte Nature on the Conformational and Supramolecular State of Pectin Macromolecules in Solution

Effect of a number of low-molecular-weight drug substances on the viscous and rheological behavior of pectin solutions in dilute and semidilute solutions regimes is studied. It is shown that the introduction of a drug substance, which is a low molecular weight electrolyte, into a dilute pectin solution leads to a change in the intrinsic viscosity of the polymer and the degree of aggregation of its macromolecules. Upon introduction of the drug substance into a semidilute pectin solution the rheological behavior of the solution changes. Presence of a drug substance of the nonelectrolyte nature in pectin solution has almost no effect on the conformational and supramolecular state of pectin and, accordingly, the viscosity characteristics of solution. It is demonstrated that the electrolyte drug substances, especially polyvalent cations, affect some practically important properties of liquid and soft dosage forms produced from pectin solutions, specifically the yield stress and the rate of drug substance release. The results obtained are explained by the polyelectrolyte nature of pectin.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Polymer Science, Series B
Polymer Science, Series B 化学-高分子科学
CiteScore
1.80
自引率
8.30%
发文量
58
审稿时长
>0 weeks
期刊介绍: Polymer Science, Series B is a journal published in collaboration with the Russian Academy of Sciences. Series B experimental and theoretical papers and reviews dealing with the synthesis, kinetics, catalysis, and chemical transformations of macromolecules, supramolecular structures, and polymer matrix-based composites (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信