电解质性质的原料药对溶液中果胶大分子构象和超分子状态的影响

IF 1 4区 化学 Q4 POLYMER SCIENCE
M. A. Afanas’eva, A. S. Shurshina, E. I. Kulish
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引用次数: 0

摘要

研究了一些低分子量的原料药对果胶溶液在稀、半稀溶液中的粘性和流变性能的影响。结果表明,在稀释的果胶溶液中加入一种低分子量电解质,会导致聚合物的特性粘度和大分子的聚集程度发生变化。在将原料药引入半稀果胶溶液后,溶液的流变行为发生了变化。果胶溶液中存在非电解质性质的原料药,对果胶的构象和超分子状态几乎没有影响,因此对溶液的粘度特性也没有影响。研究表明,电解质原料药,特别是多价阳离子,会影响果胶溶液制备的液体和软剂型的一些实际重要性质,特别是屈服应力和原料药的释放速度。所得结果可以用果胶的聚电解质性质来解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of Drug Substances of the Electrolyte Nature on the Conformational and Supramolecular State of Pectin Macromolecules in Solution

Effect of Drug Substances of the Electrolyte Nature on the Conformational and Supramolecular State of Pectin Macromolecules in Solution

Effect of a number of low-molecular-weight drug substances on the viscous and rheological behavior of pectin solutions in dilute and semidilute solutions regimes is studied. It is shown that the introduction of a drug substance, which is a low molecular weight electrolyte, into a dilute pectin solution leads to a change in the intrinsic viscosity of the polymer and the degree of aggregation of its macromolecules. Upon introduction of the drug substance into a semidilute pectin solution the rheological behavior of the solution changes. Presence of a drug substance of the nonelectrolyte nature in pectin solution has almost no effect on the conformational and supramolecular state of pectin and, accordingly, the viscosity characteristics of solution. It is demonstrated that the electrolyte drug substances, especially polyvalent cations, affect some practically important properties of liquid and soft dosage forms produced from pectin solutions, specifically the yield stress and the rate of drug substance release. The results obtained are explained by the polyelectrolyte nature of pectin.

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来源期刊
Polymer Science, Series B
Polymer Science, Series B 化学-高分子科学
CiteScore
1.80
自引率
8.30%
发文量
58
审稿时长
>0 weeks
期刊介绍: Polymer Science, Series B is a journal published in collaboration with the Russian Academy of Sciences. Series B experimental and theoretical papers and reviews dealing with the synthesis, kinetics, catalysis, and chemical transformations of macromolecules, supramolecular structures, and polymer matrix-based composites (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed
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