Carlos Ernesto Mora Palazuelos, Elsa Maribel Aguilar Medina, Mariana Melisa Avendaño Felix, Rosalio Ramos Payán, Mercedes Bermudez Cortez, Leticia Lara Avila, Adrian Herrera Salazar, Joel Murillo Llanes, Guzmán Sanchez-Schmitz, Jose Geovanni Romero Quintana
{"title":"子痫前期患者IL-6、IL-10和TNF-α基因多态性的病例对照研究。","authors":"Carlos Ernesto Mora Palazuelos, Elsa Maribel Aguilar Medina, Mariana Melisa Avendaño Felix, Rosalio Ramos Payán, Mercedes Bermudez Cortez, Leticia Lara Avila, Adrian Herrera Salazar, Joel Murillo Llanes, Guzmán Sanchez-Schmitz, Jose Geovanni Romero Quintana","doi":"10.5603/gpl.94272","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>We focused our study on examining the genotype and allele frequency of IL-6 (rs1800795), TNF-α (rs1800629) and IL-10 (rs1800872) single nucleotide polymorphisms (SNP) on preeclampsia (PE) diagnosed Mexican pregnant women.</p><p><strong>Material and methods: </strong>A case-control study was designed including 86 preeclampsia patients and 100 normotensives pregnancies from Women's Hospital of Culiacan, Mexico. Genotyping of IL-6, TNF-α and IL-10 was performed using TaqMan SNP Genotyping.</p><p><strong>Results: </strong>Not significant association was found between development of PE and genotypic (p > 0.05) and allelic (p > 0.05) frequencies of IL-6, TNF-α and IL-10 SNPs. Genotype distributions of IL-6 (p = 0.599), TNF-α (p = 0.721) and IL-10 (p = 0.761) polymorphisms in the two groups were in agreement with Hardy-Weinberg equilibrium.</p><p><strong>Conclusions: </strong>According to the findings, the IL-6, TNF-α and IL-10 SNPs are not exponents of susceptibility to developing PE.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"108-113"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"IL-6, IL-10 and TNF-α gene polymorphisms in preeclampsia: a case-control study in a Mexican population.\",\"authors\":\"Carlos Ernesto Mora Palazuelos, Elsa Maribel Aguilar Medina, Mariana Melisa Avendaño Felix, Rosalio Ramos Payán, Mercedes Bermudez Cortez, Leticia Lara Avila, Adrian Herrera Salazar, Joel Murillo Llanes, Guzmán Sanchez-Schmitz, Jose Geovanni Romero Quintana\",\"doi\":\"10.5603/gpl.94272\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>We focused our study on examining the genotype and allele frequency of IL-6 (rs1800795), TNF-α (rs1800629) and IL-10 (rs1800872) single nucleotide polymorphisms (SNP) on preeclampsia (PE) diagnosed Mexican pregnant women.</p><p><strong>Material and methods: </strong>A case-control study was designed including 86 preeclampsia patients and 100 normotensives pregnancies from Women's Hospital of Culiacan, Mexico. Genotyping of IL-6, TNF-α and IL-10 was performed using TaqMan SNP Genotyping.</p><p><strong>Results: </strong>Not significant association was found between development of PE and genotypic (p > 0.05) and allelic (p > 0.05) frequencies of IL-6, TNF-α and IL-10 SNPs. Genotype distributions of IL-6 (p = 0.599), TNF-α (p = 0.721) and IL-10 (p = 0.761) polymorphisms in the two groups were in agreement with Hardy-Weinberg equilibrium.</p><p><strong>Conclusions: </strong>According to the findings, the IL-6, TNF-α and IL-10 SNPs are not exponents of susceptibility to developing PE.</p>\",\"PeriodicalId\":94021,\"journal\":{\"name\":\"Ginekologia polska\",\"volume\":\" \",\"pages\":\"108-113\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ginekologia polska\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5603/gpl.94272\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/10/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ginekologia polska","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5603/gpl.94272","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/16 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
IL-6, IL-10 and TNF-α gene polymorphisms in preeclampsia: a case-control study in a Mexican population.
Objectives: We focused our study on examining the genotype and allele frequency of IL-6 (rs1800795), TNF-α (rs1800629) and IL-10 (rs1800872) single nucleotide polymorphisms (SNP) on preeclampsia (PE) diagnosed Mexican pregnant women.
Material and methods: A case-control study was designed including 86 preeclampsia patients and 100 normotensives pregnancies from Women's Hospital of Culiacan, Mexico. Genotyping of IL-6, TNF-α and IL-10 was performed using TaqMan SNP Genotyping.
Results: Not significant association was found between development of PE and genotypic (p > 0.05) and allelic (p > 0.05) frequencies of IL-6, TNF-α and IL-10 SNPs. Genotype distributions of IL-6 (p = 0.599), TNF-α (p = 0.721) and IL-10 (p = 0.761) polymorphisms in the two groups were in agreement with Hardy-Weinberg equilibrium.
Conclusions: According to the findings, the IL-6, TNF-α and IL-10 SNPs are not exponents of susceptibility to developing PE.
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