Mas受体在慢性肾交感神经切除雄性和雌性大鼠对血管紧张素II给药的肾血液动力学反应中的作用。

IF 2.1 Q3 CHEMISTRY, MEDICINAL
Research in Pharmaceutical Sciences Pub Date : 2023-08-20 eCollection Date: 2023-09-01 DOI:10.4103/1735-5362.383705
Hajaralsadat Hosseini-Dastgerdi, Ali-Asghar Pourshanazari, Mehdi Nematbakhsh
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引用次数: 0

摘要

背景和目的:肾血流动力学受肾交感神经和肾素-血管紧张素系统的影响。另一方面,肾交感神经去支配通过影响肾脏血流动力学来影响肾脏重量。目前的研究评估了Mas受体在基础条件下对肾血液动力学反应的作用,以及在雌性和雄性大鼠慢性肾交感神经切除术中对血管紧张素II(Ang II)的反应。实验方法:48只切除肾脏的雌性和雄性大鼠被麻醉并插管。随后,研究了慢性肾交感神经切除术对肾血管阻力(RVR)、平均动脉压(MAP)和肾血流量(RBF)等血液动力学参数的影响。此外,还研究了慢性交感神经切除术对肾脏重量的影响。发现/结果:慢性肾交感神经切除术增加了RVR,随后降低了RBF。交感神经切除后,雄性和雌性大鼠的肾灌注压也增加,而MAP没有显著变化。在对Ang II注射的反应中,肾交感神经切除术在所有实验组中引起RBF的更大下降,但不影响MAP反应。此外,慢性交感神经切除术增加了右肾切除大鼠的左肾重量。结论和意义:慢性肾交感神经切除术在基线条件下改变了系统/肾脏血流动力学,仅改变了Ang II给药后的肾脏血流动力学。此外,慢性交感神经切除术增加了肾切除大鼠的代偿性肥大。这些变化不受性别差异和Mas受体阻滞剂的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The role of Mas receptor on renal hemodynamic responses to angiotensin II administration in chronic renal sympathectomized male and female rats.

The role of Mas receptor on renal hemodynamic responses to angiotensin II administration in chronic renal sympathectomized male and female rats.

The role of Mas receptor on renal hemodynamic responses to angiotensin II administration in chronic renal sympathectomized male and female rats.

The role of Mas receptor on renal hemodynamic responses to angiotensin II administration in chronic renal sympathectomized male and female rats.
Background and purpose: Renal hemodynamics is influenced by renal sympathetic nerves and the renin-angiotensin system. On the other hand, renal sympathetic denervation impacts kidney weight by affecting renal hemodynamics. The current study evaluated the role of the Mas receptor on renal hemodynamic responses under basal conditions and in response to angiotensin II (Ang II) in chronic renal sympathectomy in female and male rats. Experimental approach: Forty-eight nephrectomized female and male rats were anesthetized and cannulated. Afterward, the effect of chronic renal sympathectomy was investigated on hemodynamic parameters such as renal vascular resistance (RVR), mean arterial pressure (MAP), and renal blood flow (RBF). In addition, the effect of chronic sympathectomy on kidney weight was examined. Findings/Results: Chronic renal sympathectomy increased RVR and subsequently decreased RBF in both sexes. Renal perfusion pressure also increased after sympathectomy in male and female rats, while MAP did not change, significantly. In response to the Ang II injection, renal sympathectomy caused a greater decrease in RBF in all experimental groups, while it did not affect the MAP response. In addition, chronic sympathectomy increased left kidney weight in right nephrectomized rats. Conclusion and implications: Chronic renal sympathectomy changed systemic/renal hemodynamics in baseline conditions and only renal hemodynamics in response to Ang II administration. Moreover, chronic sympathectomy increased compensatory hypertrophy in nephrectomized rats. These changes are unaffected by gender difference and Mas receptor blocker.
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来源期刊
Research in Pharmaceutical Sciences
Research in Pharmaceutical Sciences CHEMISTRY, MEDICINAL-
CiteScore
3.60
自引率
19.00%
发文量
50
审稿时长
34 weeks
期刊介绍: Research in Pharmaceutical Sciences (RPS) is included in Thomson Reuters ESCI Web of Science (searchable at WoS master journal list), indexed with PubMed and PubMed Central and abstracted in the Elsevier Bibliographic Databases. Databases include Scopus, EMBASE, EMCare, EMBiology and Elsevier BIOBASE. It is also indexed in several specialized databases including Scientific Information Database (SID), Google Scholar, Iran Medex, Magiran, Index Copernicus (IC) and Islamic World Science Citation Center (ISC).
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