TP53突变型骨髓瘤诊断和治疗的现状与展望。

IF 3.5 4区医学 Q3 CELL BIOLOGY

Pathobiology Pub Date : 2024-01-01 Epub Date: 2023-10-13 DOI:10.1159/000534566

Sangeetha Venugopal, Sanam Loghavi

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引用次数: 0

摘要

TP53突变的髓系肿瘤，包括急性髓系白血病（AML）和骨髓增生异常肿瘤（MDS），是出了名的治疗耐药性，结果一致较差。TP53状态是一个重要的预后指标，早期了解TP53突变/等位基因状态可能有助于适当的管理，包括合格患者的临床试验登记。到目前为止，还没有任何治疗方法显示出对TP53突变的AML或MDS的持久反应或增加的生存益处。因此，迫切需要创新疗法来改善这一臭名昭著的顽固基因组亚群的结果。在这篇综述中，我们剖析了TP53突变AML和MDS研究药物的生物学、分类、预后、当前治疗前景和早期评估。

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Current State and Future Prospects of Diagnosis and Management of TP53-Mutated Myeloid Neoplasms.

TP53-mutated myeloid neoplasms including acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are notoriously treatment resistant with uniformly poor outcomes. TP53 status is an important prognostic indicator and early knowledge of the TP53 mutation/allelic state may assist in appropriate management including clinical trial enrollment for eligible patients. Thus far, no therapy has shown to demonstrate durable response or incremental survival benefit in TP53-mutated AML or MDS. Therefore, there is an urgent need for innovative therapies to improve the outcomes in this notoriously recalcitrant genomic subset. In this review, we dissect the biology, classification, prognosis, current treatment landscape, and the early phase evaluation of investigational agents in TP53-mutated AML and MDS.

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来源期刊

Pathobiology 医学-病理学

CiteScore

8.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.