空间组学的推动者和挑战,一个技术熔炉。

IF 8.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Systems Biology Pub Date : 2023-11-09 Epub Date: 2023-10-16 DOI:10.15252/msb.202110571
Theodore Alexandrov, Julio Saez-Rodriguez, Sinem K Saka
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引用次数: 0

摘要

空间组学已经成为一个快速发展和富有成果的领域,数百篇出版物提出了在从亚细胞到生物体的空间尺度上获得任何组学数据类型的空间分辨信息的新方法。从技术发展的角度来看,空间组学是一个高度跨学科的领域,集成像和组学、空间和分子分析、测序和质谱、图像分析和生物信息学于一体。该领域的出现不仅打开了一扇了解空间生物学的窗口,还为方法开发人员创造了许多新的机会、问题和挑战。在这里,我们为技术开发人员提供了空间组学领域独特之处的视角。在简要概述了技术现状后,我们讨论了技术的推动者和挑战,并提出了我们对这个熔炉的未来应用和影响的愿景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enablers and challenges of spatial omics, a melting pot of technologies.

Spatial omics has emerged as a rapidly growing and fruitful field with hundreds of publications presenting novel methods for obtaining spatially resolved information for any omics data type on spatial scales ranging from subcellular to organismal. From a technology development perspective, spatial omics is a highly interdisciplinary field that integrates imaging and omics, spatial and molecular analyses, sequencing and mass spectrometry, and image analysis and bioinformatics. The emergence of this field has not only opened a window into spatial biology, but also created multiple novel opportunities, questions, and challenges for method developers. Here, we provide the perspective of technology developers on what makes the spatial omics field unique. After providing a brief overview of the state of the art, we discuss technological enablers and challenges and present our vision about the future applications and impact of this melting pot.

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来源期刊
Molecular Systems Biology
Molecular Systems Biology 生物-生化与分子生物学
CiteScore
18.50
自引率
1.00%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Systems biology is a field that aims to understand complex biological systems by studying their components and how they interact. It is an integrative discipline that seeks to explain the properties and behavior of these systems. Molecular Systems Biology is a scholarly journal that publishes top-notch research in the areas of systems biology, synthetic biology, and systems medicine. It is an open access journal, meaning that its content is freely available to readers, and it is peer-reviewed to ensure the quality of the published work.
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